An assessment of the clinical efficacy of intranasal desmopressin spray in the treatment of renal colic.

Lopes T, Dias JS, Marcelino J, Varela J, Ribeiro S, Dias J

BJU international1 Mar 2001Cited by 39 (Europe PMC)

PMID11251523DOI10.1046/j.1464-410x.2001.00068.xPepBankPUB-11251523

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanRandomized controlled trialEfficacy outcome
In patients with renal colic, pain at 10 minutes did not differ significantly between desmopressin and diclofenac.
In plain wordsIn patients with renal colic, pain at 10 minutes did not differ significantly between desmopressin and diclofenac.
Peptide
Desmopressin
Outcome
No significant changePain at 10 minutes
Study
n: not reported in source
Comparator
Diclofenac
Outcome group
Pain · Kidney and urinary
Studied dose
40 microg · nasal sprayAs given in this study (human).
Source sentences
Summary
At 10 min the pain decreased in all groups to a level that was not significantly different.
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 61 patients randomized into three different groups; group A received desmopressin (40 microg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac.
Report a problemFND-1125152301
02HumanRandomized controlled trialEfficacy outcome
In patients with renal colic, mean pain at 20 minutes was 5.0 with desmopressin versus 3.7 with diclofenac, although the abstract calls all three treatments equally effective at 10 and 20 min.
In plain wordsIn renal colic, pain at 20 minutes was 5.0 with desmopressin and 3.7 with diclofenac; the authors call all treatments equally effective then.
Peptide
Desmopressin
Outcome
Direction not reportedPain at 20 minutes
Study
n: not reported in source
Comparator
Diclofenac
Outcome group
Pain · Kidney and urinary
Studied dose
40 microg · nasal sprayAs given in this study (human).
Measurements
Mean pain
5 VAS score
desmopressin alone (group A)
Mean pain
3.7 VAS score
groups B and C (diclofenac; diclofenac plus desmopressin)
Source sentences
Summary
At 20 min groups B and C had similar mean pain levels (3.7), whereas in group A it was 5.0.
2 context sentences(design, population, supporting numbers)
Summary · context
The study included 61 patients randomized into three different groups; group A received desmopressin (40 microg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac.
Summary · context
All three treatments were equally effective at 10 and 20 min but at 30 min there was a stabilization/slight increase in pain level in group A.
Report a problemFND-1125152302
03HumanRandomized controlled trialEfficacy outcome
In patients with renal colic, pain at 30 minutes was 5.6 with desmopressin versus 2-3 with diclofenac.
In plain wordsIn patients with renal colic, pain at 30 minutes was higher with desmopressin than with diclofenac.
Peptide
Desmopressin
Outcome
IncreasePain at 30 minutes
Study
n: not reported in source
Comparator
Diclofenac
Outcome group
Pain · Kidney and urinary
Studied dose
40 microg · nasal sprayAs given in this study (human).
Measurements
Mean pain
5.6 VAS score
desmopressin alone (group A)
Mean pain
2 to 3 VAS score
groups B and C (diclofenac; diclofenac plus desmopressin)
Source sentences
Summary
At 30 min, groups B and C scored 2-3, and group A 5.6.
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 61 patients randomized into three different groups; group A received desmopressin (40 microg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac.
Report a problemFND-1125152303
04HumanRandomized controlled trialEfficacy outcome
In renal colic patients, pain at 10 minutes did not differ significantly between desmopressin plus diclofenac and diclofenac alone.
In plain wordsIn renal colic patients, pain at 10 minutes did not differ significantly between desmopressin plus diclofenac and diclofenac alone.
Peptide
Desmopressin
Outcome
No significant changePain at 10 minutes with adjunctive desmopressin
Study
n: not reported in source
Comparator
Diclofenac alone
Outcome group
Pain · Kidney and urinary
Studied dose
40 microg · nasal sprayAs given in this study (human).
Source sentences
Summary
At 10 min the pain decreased in all groups to a level that was not significantly different.
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 61 patients randomized into three different groups; group A received desmopressin (40 microg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac.
Report a problemFND-1125152305
05HumanRandomized controlled trialEfficacy outcome
In renal colic patients, mean pain at 20 minutes was similar (3.7) with desmopressin plus diclofenac and with diclofenac alone.
In plain wordsIn renal colic patients, pain at 20 minutes was similar, about 3.7, with or without added desmopressin.
Peptide
Desmopressin
Outcome
Not applicablePain at 20 minutes with adjunctive desmopressin
Study
n: not reported in source
Comparator
Diclofenac alone
Outcome group
Pain · Kidney and urinary
Studied dose
40 microg · nasal sprayAs given in this study (human).
Measurements
Mean pain
3.7 VAS score
groups B and C (diclofenac alone; diclofenac plus desmopressin), described as similar
Source sentences
Summary
At 20 min groups B and C had similar mean pain levels (3.7), whereas in group A it was 5.0.
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 61 patients randomized into three different groups; group A received desmopressin (40 microg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac.
Report a problemFND-1125152306
06HumanRandomized controlled trialEfficacy outcome
In renal colic patients, pain at 30 minutes scored 2-3 with both desmopressin plus diclofenac and diclofenac alone.
In plain wordsIn renal colic patients, pain at 30 minutes scored 2-3 with diclofenac, with or without added desmopressin.
Peptide
Desmopressin
Outcome
Not applicablePain at 30 minutes with adjunctive desmopressin
Study
n: not reported in source
Comparator
Diclofenac alone
Outcome group
Pain · Kidney and urinary
Studied dose
40 microg · nasal sprayAs given in this study (human).
Measurements
Mean pain
2 to 3 VAS score
groups B and C (diclofenac alone; diclofenac plus desmopressin)
Source sentences
Summary
At 30 min, groups B and C scored 2-3, and group A 5.6.
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 61 patients randomized into three different groups; group A received desmopressin (40 microg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac.
Report a problemFND-1125152307
07HumanNon-randomized trialEfficacy outcome
In patients with renal colic, pain stabilized or slightly increased at 30 minutes with desmopressin.
In plain wordsIn patients with renal colic, pain stabilized or slightly increased at 30 minutes with desmopressin.
Peptide
Desmopressin
Outcome
IncreasePain trajectory at 30 minutes
Study
n: not reported in source
Outcome group
Pain · Kidney and urinary
Studied dose
40 microg · nasal sprayAs given in this study (human).
Source sentences
Summary
All three treatments were equally effective at 10 and 20 min but at 30 min there was a stabilization/slight increase in pain level in group A.
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 61 patients randomized into three different groups; group A received desmopressin (40 microg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac.
Report a problemFND-1125152304

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 3NCT01742689

Analgesic Efficacy of Intranasal Desmopressin in Acute Renal Colic

Tehran University of Medical Sciencesn = 88Mar 2012 to est. Mar 2013

Renal Colic · Pain

Trial page ClinicalTrials.govUpdated 5 Dec 2012

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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