Skip to content

Study · Randomized controlled trial · n = 33 · 1999

3 results

Desmopressin resistant enuresis: pathogenetic and therapeutic considerations.

Nevéus T, Läckgren G, Tuvemo T, Olsson U, Stenberg A

The Journal of urology1 Dec 1999Cited by 32 (Europe PMC)

PMID10569604 (opens in a new tab)DOI10.1016/s0022-5347(05)68142-6 (opens in a new tab)PepBankPUB-10569604
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In children with resistant enuresis, time to voiding was 5.6 hours with 0.4 mg desmopressin versus 5.0 with placebo (p=0.12 overall).

    In plain wordsIn children with resistant enuresis, desmopressin 0.4 mg did not significantly delay voiding compared with placebo.

    Peptide
    Desmopressin
    Outcome
    No significant changeTime to voiding at 0.4 mg
    Study

    n = 33

    Comparator
    Placebo
    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    0.4 mg · oral · 5 nightsAs given in this study (human).

    Measurements

    Time between bedtime and voiding, 0.4 mg desmopressin
    5.6 hours
    0.4 mg desmopressin
    Time between bedtime and voiding, placebo
    5 hours
    placebo
    P value
    0.12 none
    overall comparison of placebo, 0.4 and 0.8 mg desmopressin

    Source sentences

    Summary
    Average time between bedtime and voiding was 5.0, 5.6 and 5.0 hours during the nights with placebo, and 0.4 and 0.8 mg. desmopressin, respectively (p = 0.12).
    1 context sentence
    Summary · context
    We gave 33 children with monosymptomatic nocturnal enuresis resistant to the standard 0.4 mg. oral dose of desmopressin 0.4 and 0.8 mg. desmopressin and placebo tablets for 5 nights each in a double-blind crossover fashion.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In children with resistant enuresis, time to voiding was 5.0 hours with both 0.8 mg desmopressin and placebo (p=0.12 overall).

    In plain wordsIn children with resistant enuresis, desmopressin 0.8 mg did not significantly delay voiding compared with placebo.

    Peptide
    Desmopressin
    Outcome
    No significant changeTime to voiding at 0.8 mg
    Study

    n = 33

    Comparator
    Placebo
    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    0.8 mg · oral · 5 nightsAs given in this study (human).

    Measurements

    Time between bedtime and voiding, 0.8 mg desmopressin
    5 hours
    0.8 mg desmopressin
    Time between bedtime and voiding, placebo
    5 hours
    placebo
    P value
    0.12 none
    overall comparison of placebo, 0.4 and 0.8 mg desmopressin

    Source sentences

    Summary
    Average time between bedtime and voiding was 5.0, 5.6 and 5.0 hours during the nights with placebo, and 0.4 and 0.8 mg. desmopressin, respectively (p = 0.12).
    1 context sentence
    Summary · context
    We gave 33 children with monosymptomatic nocturnal enuresis resistant to the standard 0.4 mg. oral dose of desmopressin 0.4 and 0.8 mg. desmopressin and placebo tablets for 5 nights each in a double-blind crossover fashion.
  3. 03HumanNon-randomized trialEfficacy outcome

    Among nine selected children treated openly with 0.8 mg desmopressin, five became completely dry.

    In plain wordsAmong nine selected children treated openly with desmopressin, five became completely dry.

    Peptide
    Desmopressin
    Outcome
    Not applicableComplete dryness
    Study

    n = 9

    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    0.8 mg · oralAs given in this study (human).

    Measurements

    Children completely dry
    5 children
    of 9 children treated openly with 0.8 mg desmopressin

    Source sentences

    Summary
    Of the 9 children subsequently treated with 0.8 mg. desmopressin 5 became completely dry.
    2 context sentences
    Summary · context
    All 9 children who had at least 1 dry treatment period during the randomized portion of the study then received open label treatment with 0.8 mg. desmopressin.
    Summary · context
    We gave 33 children with monosymptomatic nocturnal enuresis resistant to the standard 0.4 mg. oral dose of desmopressin 0.4 and 0.8 mg. desmopressin and placebo tablets for 5 nights each in a double-blind crossover fashion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.