Skip to content

Study · Randomized controlled trial · n = 40 · 1993

4 results

Influence of desmopressin acetate on homologous blood requirements in cardiac surgical patients pretreated with aspirin.

Dilthey G, Dietrich W, Spannagl M, Richter JA

Journal of cardiothoracic and vascular anesthesia1 Aug 1993Cited by 40 (Europe PMC)

PMID8400098 (opens in a new tab)DOI10.1016/1053-0770(93)90164-g (opens in a new tab)PepBankPUB-08400098
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In aspirin-pretreated cardiac surgical patients, median homologous blood requirements were 2 U with DDAVP versus 3.5 U with placebo.

    In plain wordsIn aspirin-pretreated cardiac surgery patients, DDAVP reduced donor blood requirements compared with placebo.

    Peptide
    Desmopressin
    Outcome
    DecreaseTotal homologous blood requirement
    Study

    n = 40

    Comparator
    Saline placebo
    Outcome group
    Blood Transfusion · Cardiovascular
    Studied dose
    0.3 microgram/kgAs given in this study (human).

    Measurements

    Blood requirement median
    2 U
    DDAVP
    Blood requirement range
    0 to 5 U
    DDAVP
    Blood requirement median
    3.5 U
    placebo
    Blood requirement range
    0 to 8 U
    placebo

    Source sentences

    Summary
    The total homologous blood requirement was significantly lower in DDAVP recipients (median 2, range, 0 to 5 U) compared to placebo (median 3.5, range, 0 to 8 U; P < 0.05).
    3 context sentences
    Summary · context
    Because patients preoperatively treated with platelet-inhibiting drugs are at increased risk of perioperative bleeding, the blood-saving effect of DDAVP was investigated in 40 male patients undergoing primary myocardial revascularization.
    Summary · context
    All patients had taken aspirin within the last 5 days prior to surgery.
    Summary · context
    In a double-blind, randomized trial, the effects of DDAVP (0.3 microgram/kg of body weight) were compared to those of saline placebo on postoperative blood loss and the need to replace blood products.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In aspirin-pretreated cardiac surgical patients, transfusion requirements were lower with DDAVP than placebo at all intraoperative and postoperative measurements.

    In plain wordsIn aspirin-pretreated cardiac surgery patients, transfusion needs were lower with DDAVP than placebo at all measured times.

    Peptide
    Desmopressin
    Outcome
    DecreaseTransfusion requirements at measured times
    Study

    n = 40

    Comparator
    Saline placebo
    Outcome group
    Blood Transfusion · Cardiovascular
    Studied dose
    0.3 microgram/kgAs given in this study (human).

    Source sentences

    Summary
    Although at all points of measurement (intraoperative and postoperative) transfusion requirement was less in the DDAVP group, hematocrit values of these patients always exceeded those of the placebo group, this difference being significant at the end of the operation.
    3 context sentences
    Summary · context
    Because patients preoperatively treated with platelet-inhibiting drugs are at increased risk of perioperative bleeding, the blood-saving effect of DDAVP was investigated in 40 male patients undergoing primary myocardial revascularization.
    Summary · context
    All patients had taken aspirin within the last 5 days prior to surgery.
    Summary · context
    In a double-blind, randomized trial, the effects of DDAVP (0.3 microgram/kg of body weight) were compared to those of saline placebo on postoperative blood loss and the need to replace blood products.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In aspirin-pretreated cardiac surgical patients, hematocrit was higher with DDAVP than placebo, significantly so at the end of surgery.

    In plain wordsIn aspirin-pretreated cardiac surgery patients, hematocrit was higher with DDAVP than placebo, significantly at surgery end.

    Peptide
    Desmopressin
    Outcome
    IncreaseHematocrit
    Study

    n = 40

    Comparator
    Saline placebo
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    0.3 microgram/kgAs given in this study (human).

    Source sentences

    Summary
    Although at all points of measurement (intraoperative and postoperative) transfusion requirement was less in the DDAVP group, hematocrit values of these patients always exceeded those of the placebo group, this difference being significant at the end of the operation.
    3 context sentences
    Summary · context
    Because patients preoperatively treated with platelet-inhibiting drugs are at increased risk of perioperative bleeding, the blood-saving effect of DDAVP was investigated in 40 male patients undergoing primary myocardial revascularization.
    Summary · context
    All patients had taken aspirin within the last 5 days prior to surgery.
    Summary · context
    In a double-blind, randomized trial, the effects of DDAVP (0.3 microgram/kg of body weight) were compared to those of saline placebo on postoperative blood loss and the need to replace blood products.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In aspirin-pretreated cardiac surgical patients, postoperative blood loss did not differ between DDAVP and placebo.

    In plain wordsIn aspirin-pretreated cardiac surgery patients, postoperative blood loss did not differ between DDAVP and placebo.

    Peptide
    Desmopressin
    Outcome
    No significant changePostoperative blood loss
    Study

    n = 40

    Comparator
    Saline placebo
    Outcome group
    Blood Loss · Cardiovascular
    Studied dose
    0.3 microgram/kgAs given in this study (human).

    Source sentences

    Summary
    Because no difference in postoperative blood loss was found
    3 context sentences
    Summary · context
    Because patients preoperatively treated with platelet-inhibiting drugs are at increased risk of perioperative bleeding, the blood-saving effect of DDAVP was investigated in 40 male patients undergoing primary myocardial revascularization.
    Summary · context
    All patients had taken aspirin within the last 5 days prior to surgery.
    Summary · context
    In a double-blind, randomized trial, the effects of DDAVP (0.3 microgram/kg of body weight) were compared to those of saline placebo on postoperative blood loss and the need to replace blood products.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 not yet recruiting · source ClinicalTrials.gov (opens in a new tab)

Not yet recruitingPhase 3NCT07012837

Transfusion Reduction in High-Bleeding-Risk Cardiac Surgery With Desmopressin

Imam Abdulrahman Bin Faisal Universityn = 112est. Jul 2025 to est. Aug 2027

Adult Patients Undergoing Cardiac Surgery · High Bleeding Risks · Planned Elective Cardiac Surgery Using CPB

Trial pageClinicalTrials.govUpdated 10 Jun 2025

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.