Skip to content

Study · Randomized controlled trial · n = 100 · 2004

1 result

Prophylactic treatment with desmopressin does not reduce postoperative bleeding after coronary surgery in patients treated with aspirin before surgery.

Pleym H, Stenseth R, Wahba A, Bjella L, Tromsdal A, Karevold A, Dale O

Anesthesia and analgesia1 Mar 2004Cited by 27 (Europe PMC)

PMID14980901 (opens in a new tab)DOI10.1213/01.ane.0000100682.84799.e8 (opens in a new tab)PepBankPUB-14980901
Publisher pagePubMedAsk about this study
Jump to 1 result

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In aspirin-treated CABG patients, blood loss was 606 (237) mL with desmopressin versus 601 (301) mL with placebo (P = 0.93).

    In plain wordsIn aspirin-treated CABG patients, desmopressin did not significantly change postoperative blood loss compared with placebo.

    Peptide
    Desmopressin
    Outcome
    No significant changePostoperative blood loss over 16 hours
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Bleeding · Cardiovascular
    Studied dose
    0.3 micro g/kgAs given in this study (human).

    Measurements

    Blood loss
    606 mL
    desmopressin
    Blood loss SD
    237 mL
    desmopressin
    Blood loss
    601 mL
    placebo
    Blood loss SD
    301 mL
    placebo
    P value
    0.93
    between groups
    Difference confidence interval
    −107 to 117 mL
    95% confidence interval

    Source sentences

    Summary
    The mean (SD) bleeding was 606 (237) mL in the desmopressin group and 601 (301) mL in the placebo group (P = 0.93), representing no significant difference (95% confidence interval, -107 to 117 mL).
    5 context sentences
    Summary · context
    Postoperative blood loss was recorded for 16 h.
    Summary · context
    We evaluated the effects of desmopressin on postoperative bleeding in CABG patients who were treated with aspirin 75 or 160 mg until the day before surgery.
    Summary · context
    The study was a prospective, randomized, double-blinded, placebo-controlled, parallel group trial.
    Summary · context
    One-hundred patients were included and divided into two groups.
    Summary · context
    One group received desmopressin 0.3 micro g/kg and the other received placebo (0.9% NaCl) after the neutralization of heparin with protamine sulfate.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.