Skip to content

Study · Randomized controlled trial · n = 104 · 2010

5 results

Efficacy of desmopressin and enuresis alarm as first and second line treatment for primary monosymptomatic nocturnal enuresis: prospective randomized crossover study.

Kwak KW, Lee YS, Park KH, Baek M

The Journal of urology18 Oct 2010Cited by 34 (Europe PMC)

PMID20961574 (opens in a new tab)DOI10.1016/j.juro.2010.08.041 (opens in a new tab)PepBankPUB-20961574
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In children with monosymptomatic nocturnal enuresis, first-line success occurred in 77.8% with desmopressin versus 82% with alarm (p=0.433).

    In plain wordsIn children with bedwetting, first-line success occurred in 77.8% with desmopressin versus 82% with alarm.

    Peptide
    Desmopressin
    Outcome
    No significant changeFirst-line successful response
    Study

    n = 104

    Comparator
    Enuresis alarm
    Outcome group
    Enuresis · Kidney and urinary
    Studied dose
    Dose not stated · 12 weeksAs given in this study (human).

    Measurements

    First-line successful result
    77.8%
    desmopressin group
    First-line successful result
    82%
    enuresis alarm group
    P value
    0.433
    first-line desmopressin vs enuresis alarm

    Source sentences

    Summary
    Following first line treatment 77.8% of the desmopressin group and 82% of the enuresis alarm group achieved a successful result, including full response in 37% and 50% of the groups, respectively (p=0.433).
    3 context sentences
    Summary · context
    A total of 104 children with monosymptomatic nocturnal enuresis were randomly assigned to either desmopressin (54) or enuresis alarm (50) as first line treatment.
    Summary · context
    Following 12 weeks of first line treatment children with a full response were evaluated for relapse 12 weeks after withdrawal of treatment.
    Summary · context
    Children with partial or no response were switched to the alternative treatment and then evaluated after 12 weeks of crossover treatment.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In children with monosymptomatic nocturnal enuresis, full response occurred in 37% with desmopressin versus 50% with alarm (p=0.433).

    In plain wordsIn children with bedwetting, full response occurred in 37% with desmopressin versus 50% with alarm.

    Peptide
    Desmopressin
    Outcome
    No significant changeFirst-line full response
    Study

    n = 104

    Comparator
    Enuresis alarm
    Outcome group
    Enuresis · Kidney and urinary
    Studied dose
    Dose not stated · 12 weeksAs given in this study (human).

    Measurements

    First-line full response
    37%
    desmopressin group
    First-line full response
    50%
    enuresis alarm group
    P value
    0.433
    first-line desmopressin vs enuresis alarm

    Source sentences

    Summary
    Following first line treatment 77.8% of the desmopressin group and 82% of the enuresis alarm group achieved a successful result, including full response in 37% and 50% of the groups, respectively (p=0.433).
    3 context sentences
    Summary · context
    A total of 104 children with monosymptomatic nocturnal enuresis were randomly assigned to either desmopressin (54) or enuresis alarm (50) as first line treatment.
    Summary · context
    Following 12 weeks of first line treatment children with a full response were evaluated for relapse 12 weeks after withdrawal of treatment.
    Summary · context
    Children with partial or no response were switched to the alternative treatment and then evaluated after 12 weeks of crossover treatment.
  3. 03HumanRandomized controlled trialEfficacy outcome

    Among children with full response, relapse occurred in 50% after desmopressin versus 12% after alarm withdrawal (p=0.005).

    In plain wordsAmong children with full response, relapse occurred in 50% after desmopressin versus 12% after alarm withdrawal.

    Peptide
    Desmopressin
    Outcome
    IncreaseRelapse after withdrawal
    Study

    n: not reported in source

    Comparator
    Enuresis alarm
    Outcome group
    Enuresis · Kidney and urinary
    Studied dose
    Dose not stated · 12 weeksAs given in this study (human).

    Measurements

    Relapse after treatment stopped
    50%
    desmopressin group, children with full response
    Relapse after treatment stopped
    12%
    enuresis alarm group, children with full response
    P value
    0.005
    relapse, desmopressin vs enuresis alarm

    Source sentences

    Summary
    Of the children with a full response 50% in the desmopressin group and 12% in the enuresis alarm group experienced a relapse when treatment stopped (p=0.005).
    3 context sentences
    Summary · context
    A total of 104 children with monosymptomatic nocturnal enuresis were randomly assigned to either desmopressin (54) or enuresis alarm (50) as first line treatment.
    Summary · context
    Following 12 weeks of first line treatment children with a full response were evaluated for relapse 12 weeks after withdrawal of treatment.
    Summary · context
    Children with partial or no response were switched to the alternative treatment and then evaluated after 12 weeks of crossover treatment.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In children, second-line success occurred in 71.4% with alarm followed by desmopressin versus 67.8% with the reverse sequence (p=0.961).

    In plain wordsIn children, second-line success occurred in 71.4% with alarm then desmopressin versus 67.8% with desmopressin then alarm.

    Peptide
    Desmopressin
    Outcome
    No significant changeSecond-line successful response
    Study

    n: not reported in source

    Comparator
    Desmopressin followed by enuresis alarm
    Outcome group
    Enuresis · Kidney and urinary
    Studied dose
    Dose not stated · 12 weeksAs given in this study (human).

    Measurements

    Second-line successful result
    71.4%
    enuresis alarm-desmopressin group
    Second-line successful result
    67.8%
    desmopressin-enuresis alarm group
    P value
    0.961
    second-line crossover groups

    Source sentences

    Summary
    Following second line crossover treatment 71.4% of the enuresis alarm-desmopressin group and 67.8% of the desmopressin-enuresis alarm group achieved a successful result, including full response in 47.6% and 45.2% of the groups, respectively (p=0.961).
    3 context sentences
    Summary · context
    A total of 104 children with monosymptomatic nocturnal enuresis were randomly assigned to either desmopressin (54) or enuresis alarm (50) as first line treatment.
    Summary · context
    Following 12 weeks of first line treatment children with a full response were evaluated for relapse 12 weeks after withdrawal of treatment.
    Summary · context
    Children with partial or no response were switched to the alternative treatment and then evaluated after 12 weeks of crossover treatment.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In children, second-line full response occurred in 47.6% with alarm followed by desmopressin versus 45.2% with the reverse sequence (p=0.961).

    In plain wordsIn children, full response occurred in 47.6% with alarm then desmopressin versus 45.2% with desmopressin then alarm.

    Peptide
    Desmopressin
    Outcome
    No significant changeSecond-line full response
    Study

    n: not reported in source

    Comparator
    Desmopressin followed by enuresis alarm
    Outcome group
    Enuresis · Kidney and urinary
    Studied dose
    Dose not stated · 12 weeksAs given in this study (human).

    Measurements

    Second-line full response
    47.6%
    enuresis alarm-desmopressin group
    Second-line full response
    45.2%
    desmopressin-enuresis alarm group
    P value
    0.961
    second-line crossover groups

    Source sentences

    Summary
    Following second line crossover treatment 71.4% of the enuresis alarm-desmopressin group and 67.8% of the desmopressin-enuresis alarm group achieved a successful result, including full response in 47.6% and 45.2% of the groups, respectively (p=0.961).
    3 context sentences
    Summary · context
    A total of 104 children with monosymptomatic nocturnal enuresis were randomly assigned to either desmopressin (54) or enuresis alarm (50) as first line treatment.
    Summary · context
    Following 12 weeks of first line treatment children with a full response were evaluated for relapse 12 weeks after withdrawal of treatment.
    Summary · context
    Children with partial or no response were switched to the alternative treatment and then evaluated after 12 weeks of crossover treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.