Melanotan II studies: 324 papers with results
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- Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.
Wilson EA · American journal of physiology. Endocrinology and metabolism · 2021
Animal study (in vivo) · mouse · 2 results
- Modulatory function of NMDA glutamate receptor on MC3/MC4 receptors agonist-induced hypophagia in neonatal meat-type chicken.
Ahmadi F · Veterinary research communications · 2017
Animal study (in vivo) · chicken · 3 results
- Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice.
Mc Allister E · Physiology & behavior · 2015
Animal study (in vivo) · mouse · 1 result
- Profound and rapid reduction in body temperature induced by the melanocortin receptor agonists.
Xu Y · Biochemical and biophysical research communications · 2014
Animal study (in vivo) · 6 results
- Effects of ghrelin, corticotrophin-releasing hormone, and melanotan-II on food intake in rats with paraventricular nucleus lesions.
Wang J · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2007
Animal study (in vivo) · rat · 2 results
- Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats.
van Dijk G · Endocrinology · 2005
Animal study (in vivo) · rat · 5 results
- Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide.
Lan EL · Journal of pharmaceutical sciences · 1994
Animal study (in vivo) · rat · 3 results
- Hindbrain melanocortin 3/4 receptors modulate the food intake and body weight suppressive effects of the GLP-1 receptor agonist, liraglutide.
Fortin SM · Physiology & behavior · 2020
Animal study (in vivo) · 4 results
- Control of appetite, blood glucose, and blood pressure during melanocortin-4 receptor activation in normoglycemic and diabetic NPY-deficient mice.
da Silva AA · American journal of physiology. Regulatory, integrative and comparative physiology · 2018
Animal study (in vivo) · mouse · 8 results
- The nutritional induction of COUP-TFII gene expression in ventromedial hypothalamic neurons is mediated by the melanocortin pathway.
Sabra-Makke L · PloS one · 2010
Animal study (in vivo) · mouse · 4 results
- Intermittent MTII application evokes repeated anorexia and robust fat and weight loss.
Zhang Y · Peptides · 2010
Animal study (in vivo) · rat · 8 results
- Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.
Eliason NL · Neuropeptides · 2022
Animal study (in vivo) · mouse · 5 results
- Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus.
Luchtman DW · PloS one · 2015
Animal study (in vivo) · rat · 2 results
- The use of telemetry technology to test the proerectile effect of melanotan-II (MT-II) in conscious rats.
Giuliano F · European urology · 2005
Animal study (in vivo) · rat · 2 results
- The effects of the melanocortin agonist (MT-II) on subcutaneous and visceral adipose tissue in rodents.
Strader AD · The Journal of pharmacology and experimental therapeutics · 2007
Animal study (in vivo) · mouse and rat · 7 results
- Evaluation of the role of melanocortin 3 and 4 receptors in leptin-stimulated and spontaneous growth hormone secretion in rats.
Watanobe H · Neuroendocrinology · 2003
Animal study (in vivo) · rat · 1 result
- Evidence for a feeding related association between melanocortin in the NTS and Neuropeptide-Y in the PVN.
Kim EM · Appetite · 2023
Animal study (in vivo) · rat · 2 results
- Anatomical dissociation of melanocortin receptor agonist effects on taste- and gut-sensitive feeding processes.
Baird JP · American journal of physiology. Regulatory, integrative and comparative physiology · 2011
Animal study (in vivo) · 8 results
- Melanocortin agonism in a social context selectively activates nucleus accumbens in an oxytocin-dependent manner.
Ford CL · Neuropharmacology · 2024
Animal study (in vivo) · prairie vole · 2 results
- Zebrafish Bioassay for Screening Therapeutic Candidates Based on Melanotrophic Activity.
Hong TI · International journal of molecular sciences · 2021
Animal study (in vivo) · zebrafish · 1 result
- CAPS2 deficiency induces proopiomelanocortin accumulation in pituitary and affects food intake behavior in mice.
Fujima S · Neuroscience letters · 2020
Animal study (in vivo) · mouse · 2 results
- Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition.
Wu JC · International journal of molecular sciences · 2020
Animal study (in vivo) · mouse · 14 results
- Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction.
Côté I · Canadian journal of physiology and pharmacology · 2017
Animal study (in vivo) · rat · 4 results
- Genetic and pharmacological mouse models of chronic melanocortin activation show enhanced baroreflex control of heart rate.
Rinne P · Regulatory peptides · 2013
Animal study (in vivo) · mouse · 3 results
- Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.
Inozemtseva LS · European journal of pharmacology · 2024
Animal study (in vivo) · rat · 10 results
- Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets.
van den Heuvel JK · Frontiers in behavioral neuroscience · 2015
Animal study (in vivo) · rat · 2 results
- Treatment with a melanocortin agonist improves abnormal lipid metabolism in streptozotocin-induced diabetic mice.
Leckstrom A · Neuropeptides · 2011
Animal study (in vivo) · mouse · 12 results
- Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.
Liu H · Endocrinology · 2024
Animal study (in vivo) · mouse · 2 results
- Melanotan-II reverses memory impairment induced by a short-term HF diet.
Wekwejt P · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
Animal study (in vivo) · zebrafish · 3 results
- Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase-activating polypeptide deficient mice.
McMillan TR · Experimental physiology · 2021
Animal study (in vivo) · mouse · 2 results
- Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.
Côté I · Canadian journal of physiology and pharmacology · 2018
Animal study (in vivo) · rat · 3 results
- [Energy homeostasis regulated by an adipocyte-derived hormone--mechanism of leptin resistance and role of hypothalamic melanocortin signaling].
Masuzaki H · Nihon rinsho. Japanese journal of clinical medicine · 2009
Animal study (in vivo) · mouse · 4 results
- Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides.
Nijenhuis WA · European journal of pharmacology · 2004
Animal study (in vivo) · rat · 1 result
- Co-treatment with melanotan-II, a potent melanocortin, does not protect against cisplatin ototoxicity.
Wolters FL · Hearing research · 2002
Animal study (in vivo) · guinea pig · 2 results
- Multiple metabolic signals in the CeA regulate feeding: The role of AMPK.
Castro G · Molecular and cellular endocrinology · 2024
Animal study (in vivo) · rat · 3 results
- [STUDYING THE ROLE OF BRAIN MELANOCORTIN RECEPTORS IN THE SUPPRESSING OF FOOD INTAKE UNDER ETHER STRESS IN MICE].
Bazhan NM · Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova · 2015
Animal study (in vivo) · mouse · 2 results
- Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons.
Wan S · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008
Ex vivo tissue · rat · 5 results
- CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs.
Hisadome K · Diabetes · 2011
Ex vivo tissue · mouse · 1 result
- Agouti-related peptide and MC3/4 receptor agonists both inhibit excitatory hypothalamic ventromedial nucleus neurons.
Fu LY · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008
Ex vivo tissue · mouse · 5 results
- Neuropeptides, including neuropeptide Y and melanocortins, mediate lipolysis in murine adipocytes.
Bradley RL · Obesity research · 2005
Ex vivo tissue · mouse · 2 results
- Alpha-melanocyte-stimulating hormone suppresses antigen-induced lymphocyte proliferation in humans independently of melanocortin 1 receptor gene status.
Cooper A · Journal of immunology (Baltimore, Md. : 1950) · 2005
Ex vivo tissue · 1 result
- Characterization of the sea bass melanocortin 5 receptor: a putative role in hepatic lipid metabolism.
Sánchez E · The Journal of experimental biology · 2009
Ex vivo tissue · sea bass · 1 result
- AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting.
Gupta R · Endocrinology · 2017
Ex vivo tissue · mouse · 2 results
- Activation of the melanocortin-4 receptor causes enhanced excitation in presympathetic paraventricular neurons in obese Zucker rats.
Ye ZY · Regulatory peptides · 2011
Ex vivo tissue · rat · 6 results
- Regulation of neuropeptide Y release from hypothalamic slices by melanocortin-4 agonists and leptin.
King PJ · Peptides · 2000
Ex vivo tissue · rat · 2 results
- Food deprivation decreases responsiveness of ventromedial hypothalamic neurons to melanocortins.
Li YZ · Journal of neuroscience research · 2004
Ex vivo tissue · rat · 3 results
- Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors.
Michael NJ · Molecular metabolism · 2020
Ex vivo tissue · mouse · 4 results
- The role of the melanocortin 3 receptor in mediating the effects of gamma-MSH peptides on the adrenal.
Harmer SC · Endocrine research · 2004
Ex vivo tissue · rat · 1 result
- Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor.
Haskell-Luevano C · Regulatory peptides · 2001
In vitro (cells) · 1 result
- Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.
Xiang Z · Biochemistry · 2006
In vitro (cells) · 1 result