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Study · Animal study (in vivo) · rat · 2024

10 results

Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.

Inozemtseva LS, Yatsenko KA, Glazova NY, Kamensky AA, Myasoedov NF, Levitskaya NG, Grivennikov IA, Dolotov OV

European journal of pharmacology21 Oct 2024Cited by 2 (Europe PMC)

PMID39442746 (opens in a new tab)DOI10.1016/j.ejphar.2024.177068 (opens in a new tab)PepBankPUB-39442746
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats under chronic unpredictable stress, Semax reversed or substantially attenuated stress-induced anhedonia.

    In plain wordsIn rats under chronic stress, Semax reversed or reduced the loss of interest in sweet drink that stress caused.

    Peptide
    Semax
    Outcome
    DecreaseCUS-induced anhedonia (sucrose preference test)
    Study

    ratn: not reported in source

    chronic unpredictable stress (CUS) model of depression
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    60 nmol/kg of body weight daily · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.
    1 context sentence
    Summary · context
    Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats under chronic unpredictable stress, Semax reversed or substantially attenuated the suppression of body weight gain.

    In plain wordsIn rats under chronic stress, Semax reversed or reduced the stress-related slowing of weight gain.

    Peptide
    Semax
    Outcome
    IncreaseCUS-induced body weight gain suppression
    Study

    ratn: not reported in source

    chronic unpredictable stress (CUS) model of depression
    Comparator
    Saline
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    60 nmol/kg of body weight daily · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.
    1 context sentence
    Summary · context
    Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats under chronic unpredictable stress, Semax reversed or substantially attenuated adrenal hypertrophy.

    In plain wordsIn rats under chronic stress, Semax reversed or reduced the enlargement of the adrenal glands that stress caused.

    Peptide
    Semax
    Outcome
    DecreaseCUS-induced adrenal hypertrophy
    Study

    ratn: not reported in source

    chronic unpredictable stress (CUS) model of depression
    Comparator
    Saline
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    60 nmol/kg of body weight daily · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.
    1 context sentence
    Summary · context
    Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats under chronic unpredictable stress, Semax reversed or substantially attenuated the stress-induced decrease in hippocampal BDNF.

    In plain wordsIn rats under chronic stress, Semax reversed or reduced the stress-related drop in the brain growth factor BDNF.

    Peptide
    Semax
    Outcome
    IncreaseHippocampal BDNF level
    Study

    ratn: not reported in source

    chronic unpredictable stress (CUS) model of depression
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    60 nmol/kg of body weight daily · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.
    1 context sentence
    Summary · context
    Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, Semax had no effect on immobility duration in the forced swim test.

    In plain wordsIn rats, Semax did not change how long the animals stayed immobile in the forced swim test.

    Peptide
    Semax
    Outcome
    No significant changeImmobility duration in forced swim test
    Study

    ratn: not reported in source

    chronic unpredictable stress (CUS) model of depression
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    60 nmol/kg of body weight daily · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In the forced swim test, no effects of the CUS procedure or peptides on the duration of rat immobility were detected.
    1 context sentence
    Summary · context
    Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic unpredictable stress, melanotan II (with Semax in the same study) reversed or substantially attenuated stress-induced anhedonia.

    In plain wordsIn stressed rats, melanotan II reversed or reduced the loss of interest in sweet drink that stress caused.

    Peptide
    Melanotan II
    Outcome
    DecreaseAnhedonia (sucrose preference)
    Study

    ratn: not reported in source

    Chronic unpredictable stress (CUS) model, male Sprague-Dawley rats
    Comparator
    Saline-treated stressed rats
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    60 nmol/kg body weight · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.
    1 context sentence
    Summary · context
    Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic unpredictable stress, melanotan II (with Semax in the same study) reversed or substantially attenuated the stress-induced suppression of body weight gain.

    In plain wordsIn stressed rats, melanotan II reversed or reduced the loss of weight gain that stress caused.

    Peptide
    Melanotan II
    Outcome
    IncreaseBody weight gain suppression
    Study

    ratn: not reported in source

    Chronic unpredictable stress (CUS) model, male Sprague-Dawley rats
    Comparator
    Saline-treated stressed rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    60 nmol/kg body weight · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.
    1 context sentence
    Summary · context
    Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with chronic unpredictable stress, melanotan II (with Semax in the same study) reversed or substantially attenuated stress-induced adrenal hypertrophy.

    In plain wordsIn stressed rats, melanotan II reversed or reduced the enlargement of the adrenal glands that stress caused.

    Peptide
    Melanotan II
    Outcome
    DecreaseAdrenal hypertrophy
    Study

    ratn: not reported in source

    Chronic unpredictable stress (CUS) model, male Sprague-Dawley rats
    Comparator
    Saline-treated stressed rats
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    60 nmol/kg body weight · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.
    1 context sentence
    Summary · context
    Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats with chronic unpredictable stress, melanotan II (with Semax in the same study) reversed or substantially attenuated the stress-induced decrease in hippocampal BDNF.

    In plain wordsIn stressed rats, melanotan II reversed or reduced the drop in brain BDNF levels that stress caused.

    Peptide
    Melanotan II
    Outcome
    IncreaseHippocampal BDNF level
    Study

    ratn: not reported in source

    Chronic unpredictable stress (CUS) model, male Sprague-Dawley rats
    Comparator
    Saline-treated stressed rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    60 nmol/kg body weight · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF.
    1 context sentence
    Summary · context
    Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats, melanotan II (with Semax in the same study) did not change immobility time in the forced swim test.

    In plain wordsIn rats, melanotan II did not change how long the animals stayed still in the forced swim test.

    Peptide
    Melanotan II
    Outcome
    No significant changeImmobility time in forced swim test
    Study

    ratn: not reported in source

    Chronic unpredictable stress (CUS) model, male Sprague-Dawley rats
    Comparator
    Saline-treated stressed rats
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    60 nmol/kg body weight · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In the forced swim test, no effects of the CUS procedure or peptides on the duration of rat immobility were detected.
    1 context sentence
    Summary · context
    Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 38Current

    28 Oct 2026, 02:04 UTC

    The same notice was added 36 times, first on 9 Oct 2026, 19:08 UTC. The status did not change between them.

    Study results updated

  2. Version 2

    9 Oct 2026, 03:04 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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