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Study · Animal study (in vivo) · rat · 2018

3 results

Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.

Côté I, Green SM, Morgan D, Carter CS, Tümer N, Scarpace PJ

Canadian journal of physiology and pharmacology13 Nov 2017Cited by 1 (Europe PMC)

PMID29131966 (opens in a new tab)PMCIDPMC12412181 (opens in a new tab)DOI10.1139/cjpp-2017-0440 (opens in a new tab)PepBankPUB-29131966
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, central MTII infusion caused body mass loss that was only partly explained by caloric restriction and was independent of the initial hypophagia over the long term.

    In plain wordsIn rats, MTII infused into the brain lowered body mass, and this loss was only partly due to eating less.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody mass loss independent of caloric reduction
    Study

    ratn: not reported in source

    Comparator
    Pair-fed and control rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · central infusionAs given in this study (rat).

    Source sentences

    Summary
    The present study demonstrates that central MTII-mediated body mass loss is only partially mediated by caloric restriction, and the long-term body mass loss is independent of the initial hypophagia.
    1 context sentence
    Summary · context
    To examine the contribution of caloric reduction to long-term body mass loss in response to MTII, we centrally infused MTII or vehicle in ad libitum fed (MTII and Control) animals in comparison with a group of animals that were pair-fed (PF) to the MTII group.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, central MTII induced a rapid and sustained fat mass loss independently of caloric reduction.

    In plain wordsIn rats, MTII infused into the brain lowered fat mass quickly and lastingly, even compared with rats fed the same amount.

    Peptide
    Melanotan II
    Outcome
    DecreaseFat mass loss independent of caloric reduction
    Study

    ratn: not reported in source

    Comparator
    Pair-fed rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · central infusionAs given in this study (rat).

    Source sentences

    Summary
    More importantly, central MTII administration induced a rapid but sustained fat mass loss, independently of caloric reduction.
    1 context sentence
    Summary · context
    To examine the contribution of caloric reduction to long-term body mass loss in response to MTII, we centrally infused MTII or vehicle in ad libitum fed (MTII and Control) animals in comparison with a group of animals that were pair-fed (PF) to the MTII group.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    MTII-treated rats kept their lean/fat mass ratio throughout the study, whereas pair-fed rats had a transient reduction.

    In plain wordsIn rats, MTII-treated animals kept their lean-to-fat ratio, while rats fed the same amount briefly lost it.

    Peptide
    Melanotan II
    Outcome
    No significant changeLean/fat mass ratio
    Study

    ratn: not reported in source

    Comparator
    Pair-fed rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · central infusionAs given in this study (rat).

    Source sentences

    Summary
    MTII-treated animals preserved their lean/fat mass ratio throughout the study, whereas PF animals underwent a transient reduction of lean/fat mass ratio that was only normalized when food intake returned to Control level.
    1 context sentence
    Summary · context
    To examine the contribution of caloric reduction to long-term body mass loss in response to MTII, we centrally infused MTII or vehicle in ad libitum fed (MTII and Control) animals in comparison with a group of animals that were pair-fed (PF) to the MTII group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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