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Study · Ex vivo tissue · rat · 2011

6 results

Activation of the melanocortin-4 receptor causes enhanced excitation in presympathetic paraventricular neurons in obese Zucker rats.

Ye ZY, Li DP

Regulatory peptides16 Oct 2010Cited by 23 (Europe PMC)

PMID20937332 (opens in a new tab)DOI10.1016/j.regpep.2010.10.001 (opens in a new tab)PepBankPUB-20937332
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In brain slices from lean and obese Zucker rats, melanotan II increased the firing activity of presympathetic paraventricular neurons in a concentration-dependent manner.

    In plain wordsIn rat brain slices, melanotan II made certain nerve cells fire more, with higher concentrations having a larger effect.

    Peptide
    Melanotan II
    Outcome
    IncreaseFiring activity of PVN presympathetic neurons
    Study

    ratn: not reported in source

    brain slices from obese and lean Zucker rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The MC4R agonists melanotan II (MTII) and α-melanocyte-stimulating hormone (α-MSH) increased the firing activity and depolarized the labeled PVN neurons from both LZRs and OZRs in a concentration-dependent manner.
    1 context sentence
    Summary · context
    We performed whole-cell patch-clamp recordings on retrogradely labeled PVN neurons projecting to the rostral ventrolateral medulla in brain slices from obese zucker rats (OZRs) and lean zucker rats (LZRs).
  2. 02LabEx vivo tissueMechanism

    In brain slices from lean and obese Zucker rats, melanotan II depolarized presympathetic paraventricular neurons in a concentration-dependent manner.

    In plain wordsIn rat brain slices, melanotan II depolarized certain nerve cells in a concentration-dependent way.

    Peptide
    Melanotan II
    Outcome
    IncreaseDepolarization of PVN presympathetic neurons
    Study

    ratn: not reported in source

    brain slices from obese and lean Zucker rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The MC4R agonists melanotan II (MTII) and α-melanocyte-stimulating hormone (α-MSH) increased the firing activity and depolarized the labeled PVN neurons from both LZRs and OZRs in a concentration-dependent manner.
    1 context sentence
    Summary · context
    We performed whole-cell patch-clamp recordings on retrogradely labeled PVN neurons projecting to the rostral ventrolateral medulla in brain slices from obese zucker rats (OZRs) and lean zucker rats (LZRs).
  3. 03LabEx vivo tissueMechanism

    Melanotan II produced a significantly greater increase in firing activity of paraventricular neurons in obese than in lean Zucker rats.

    In plain wordsIn rat brain slices, melanotan II raised nerve cell firing more in obese rats than in lean rats.

    Peptide
    Melanotan II
    Outcome
    IncreaseFiring response to melanotan II, obese versus lean
    Study

    ratn: not reported in source

    brain slices from obese and lean Zucker rats
    Comparator
    Lean Zucker rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTII produced significant greater increase in the firing activity in OZRs than in LZRs.
    1 context sentence
    Summary · context
    We performed whole-cell patch-clamp recordings on retrogradely labeled PVN neurons projecting to the rostral ventrolateral medulla in brain slices from obese zucker rats (OZRs) and lean zucker rats (LZRs).
  4. 04LabEx vivo tissueMechanism

    In paraventricular neurons from obese and lean Zucker rats, the MC4R antagonist SHU9119 abolished the melanotan II-induced increase in firing rate.

    In plain wordsIn rat brain slices, the blocker SHU9119 stopped melanotan II from raising nerve cell firing.

    Peptide
    Melanotan II
    Outcome
    No significant changeMelanotan II firing response after SHU9119
    Study

    ratn: not reported in source

    brain slices from obese and lean Zucker rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Blocking MC4R with the specific antagonist SHU9119 had no effect on the basal firing rate but abolished the MTII-induced increase in the firing rate in both OZRs and LZRs.
    1 context sentence
    Summary · context
    We performed whole-cell patch-clamp recordings on retrogradely labeled PVN neurons projecting to the rostral ventrolateral medulla in brain slices from obese zucker rats (OZRs) and lean zucker rats (LZRs).
  5. 05LabEx vivo tissueMechanism

    Intracellular dialysis of guanosine 5'-O-(2-thodiphosphate), but not kynurenic acid and bicuculline, eliminated the melanotan II-induced increase in firing activity.

    In plain wordsIn rat brain slices, blocking G-protein signaling inside the cell stopped the melanotan II rise in nerve cell firing.

    Peptide
    Melanotan II
    Outcome
    No significant changeMelanotan II firing response after intracellular GDP-beta-S
    Study

    ratn: not reported in source

    brain slices from obese and lean Zucker rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, intracellular dialysis of guanosine 5'-O-(2-thodiphosphate), but not bath application of kynurenic acid and bicuculline, eliminated the MTII-induced increase in firing activity.
    1 context sentence
    Summary · context
    We performed whole-cell patch-clamp recordings on retrogradely labeled PVN neurons projecting to the rostral ventrolateral medulla in brain slices from obese zucker rats (OZRs) and lean zucker rats (LZRs).
  6. 06LabEx vivo tissueMechanism

    Melanotan II had no effect on the frequency and amplitude of excitatory and inhibitory postsynaptic currents in labeled paraventricular neurons.

    In plain wordsIn rat brain slices, melanotan II did not change synaptic currents in these nerve cells.

    Peptide
    Melanotan II
    Outcome
    No significant changeGlutamatergic and GABAergic synaptic currents
    Study

    ratn: not reported in source

    brain slices from obese and lean Zucker rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, MTII had no effect on the frequency and amplitude of glutamatergic excitatory postsynaptic currents and GABAergic inhibitory postsynaptic currents in labeled PVN neurons.
    1 context sentence
    Summary · context
    We performed whole-cell patch-clamp recordings on retrogradely labeled PVN neurons projecting to the rostral ventrolateral medulla in brain slices from obese zucker rats (OZRs) and lean zucker rats (LZRs).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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