In a perfused adrenal cell column, the MC3-R agonist MTII could not mimic pro-gamma-MSH potentiation of ACTH-induced steroidogenesis.
In plain wordsIn lab tests on adrenal cells, MTII did not reproduce the boost that pro-gamma-MSH gives to ACTH-driven steroid production.
- Peptide
- Melanotan II
- Outcome
- No significant changePotentiation of ACTH-induced steroidogenesis (mimicry of pro-gamma-MSH)
- Study
ratn: not reported in source
Continuously perfused adrenal cell column- Outcome group
- Receptor activity and mechanism · Endocrine and hormones
- Studied dose
- Dose not stated
Source sentences
We found that MTII could not mimic, and SHU9119 could not block pro-gamma-MSH mediated potentiation of ACTH-induced steroidogenesis.
1 context sentence(design, population, supporting numbers)
Using a continuously perfused adrenal cell column system, we have tested the hypothesis that gamma-MSH peptides exert their effect through the Melanocortin 3 Receptor (MC3-R), since this is the only known receptor to have high affinity for gamma-MSH peptides and has been suggested to be expressed in the rat adrenal.