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Study · Animal study (in vivo) · prairie vole · 2024

2 results

Melanocortin agonism in a social context selectively activates nucleus accumbens in an oxytocin-dependent manner.

Ford CL, McDonough AA, Horie K, Young LJ

Neuropharmacology20 Jan 2024Cited by 3 (Europe PMC)

PMID38253222 (opens in a new tab)PMCIDPMC10923148 (opens in a new tab)DOI10.1016/j.neuropharm.2024.109848 (opens in a new tab)PepBankPUB-38253222
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In prairie voles in non-social contexts, MTII activated only the hypothalamic paraventricular nucleus, based on Fos expression.

    In plain wordsIn prairie voles alone, MTII switched on only one brain region, the hypothalamic paraventricular nucleus.

    Peptide
    Melanotan II
    Outcome
    IncreaseFos activation of paraventricular nucleus in non-social context
    Study

    prairie volen: not reported in source

    Male and female prairie voles in social interactions
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In non-social contexts, MTII only activated hypothalamic paraventricular nucleus, a primary site of oxytocin synthesis.
    2 context sentences
    Summary · context
    We assessed its effect on oxytocin-dependent activity in brain regions subserving social learning using Fos expression as a proxy for neuronal activation.
    Summary · context
    To model pharmacological activation of the endogenous oxytocin system during behavioral therapy, we administered MTII prior to social interactions between male and female voles.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In prairie voles during social interactions, MTII selectively increased oxytocin-dependent activation of the nucleus accumbens, based on Fos expression.

    In plain wordsIn prairie voles during social contact, MTII selectively increased activity in the nucleus accumbens, a brain region for social learning.

    Peptide
    Melanotan II
    Outcome
    IncreaseOxytocin-dependent Fos activation of nucleus accumbens during social interaction
    Study

    prairie volen: not reported in source

    Male and female prairie voles in social interactions
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, during social interactions, MTII selectively increased oxytocin-dependent activation of nucleus accumbens, a site critical for social learning.
    2 context sentences
    Summary · context
    We assessed its effect on oxytocin-dependent activity in brain regions subserving social learning using Fos expression as a proxy for neuronal activation.
    Summary · context
    To model pharmacological activation of the endogenous oxytocin system during behavioral therapy, we administered MTII prior to social interactions between male and female voles.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:04 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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