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Study · Animal study (in vivo) · mouse · 2024

2 results

Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.

Liu H, Liu Z, Wong HK, Xu N, Liu Q, Li Y, Liu Y, Wong H, Burt ME, Jossy SV, Han J, He Y

Endocrinology1 May 2024Cited by 1 (Europe PMC)

PMID38815086 (opens in a new tab)PMCIDPMC12785533 (opens in a new tab)DOI10.1210/endocr/bqae063 (opens in a new tab)PepBankPUB-38815086
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Htr2cF327L/Y mice with 5-HT2CR loss of function, melanotan II suppressed feeding.

    In plain wordsIn mice with a faulty 5-HT2C receptor gene, melanotan II reduced feeding.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake
    Study

    mousen: not reported in source

    Htr2cF327L/Y mice with loss-of-function 5-HT2CR
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similarly, administration of melanotan II, an agonist of the melanocortin receptor 4 (MC4R), effectively suppresses feeding and weight gain in Htr2cF327L/Y mice.
    1 context sentence
    Summary · context
    In this study, we aimed to investigate the potential therapeutic strategies for ameliorating hyperphagia, hyperglycemia, and obesity associated with a loss-of-function mutation in the Htr2c gene (Htr2cF327L/Y).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Htr2cF327L/Y mice with 5-HT2CR loss of function, melanotan II suppressed weight gain.

    In plain wordsIn mice with a faulty 5-HT2C receptor gene, melanotan II reduced weight gain.

    Peptide
    Melanotan II
    Outcome
    DecreaseWeight gain
    Study

    mousen: not reported in source

    Htr2cF327L/Y mice with loss-of-function 5-HT2CR
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similarly, administration of melanotan II, an agonist of the melanocortin receptor 4 (MC4R), effectively suppresses feeding and weight gain in Htr2cF327L/Y mice.
    1 context sentence
    Summary · context
    In this study, we aimed to investigate the potential therapeutic strategies for ameliorating hyperphagia, hyperglycemia, and obesity associated with a loss-of-function mutation in the Htr2c gene (Htr2cF327L/Y).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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