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Study · Animal study (in vivo) · rat · 2005

2 results

The use of telemetry technology to test the proerectile effect of melanotan-II (MT-II) in conscious rats.

Giuliano F, Rössler AS, Clément P, Droupy S, Alexandre L, Bernabé J

European urology20 Mar 2005Cited by 6 (Europe PMC)

PMID15967265 (opens in a new tab)DOI10.1016/j.eururo.2005.02.023 (opens in a new tab)PepBankPUB-15967265
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, melanotan II at 1 mg/kg significantly increased overall erectile activity compared with saline.

    In plain wordsIn conscious rats, melanotan II at 1 mg/kg increased erectile activity more than saline.

    Peptide
    Melanotan II
    Outcome
    IncreaseOverall erectile activity (intracavernosal pressure) in conscious rats
    Study

    ratn: not reported in source

    Conscious, freely moving rats with telemetric ICP sensor
    Comparator
    Saline
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    1 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    In conscious rats, MT-II (1 mg/kg) significantly increased overall erectile activity compared to saline.
    1 context sentence
    Summary · context
    Adult rats were implanted in the corpus cavernosum with a pressure sensor which permitted telemetric monitoring of ICP in freely moving animals following MT-II (0.1, 0.3 and 1 mg/kg) or saline i.v. injections.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, the melanotan II-induced increase in overall erectile activity was not statistically significant, although the pattern was similar to that in conscious rats.

    In plain wordsIn anesthetized rats, melanotan II did not clearly raise erectile activity versus saline, though the pattern looked similar to conscious rats.

    Peptide
    Melanotan II
    Outcome
    No significant changeOverall erectile activity (intracavernosal pressure) in anesthetized rats
    Study

    ratn: not reported in source

    Anesthetized rats
    Comparator
    Saline
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    0.1, 0.3 or 1 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    In anesthetized rats, MT-II-induced increase in overall erectile activity was not statistically significant but displayed a similar pattern.
    1 context sentence
    Summary · context
    ICP was also measured after MT-II (0.1, 0.3 or 1 mg/kg) or saline i.v. delivery in anesthetized rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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