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Study · Animal study (in vivo) · mouse · 2021

2 results

Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.

Wilson EA, Sun H, Cui Z, Jahnke MT, Pandey M, Metzger P, Gavrilova O, Chen M, Weinstein LS

American journal of physiology. Endocrinology and metabolism9 Nov 2020Cited by 8 (Europe PMC)

PMID33166186 (opens in a new tab)PMCIDPMC8260363 (opens in a new tab)DOI10.1152/ajpendo.00059.2020 (opens in a new tab)PepBankPUB-33166186
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with dorsomedial hypothalamus Gq/11alpha deletion, melanotan II still acutely stimulated energy expenditure, with no defect compared with controls.

    In plain wordsIn mice lacking Gq/11alpha in one brain area, melanotan II still raised energy use as it did in control mice.

    Peptide
    Melanotan II
    Outcome
    No significant changeAcute stimulation of energy expenditure by melanotan II
    Study

    mousen: not reported in source

    Mice with dorsomedial hypothalamus deletion of Gq/11alpha (DMHGq/11KO)
    Comparator
    Control mice with AAV-GFP
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DMHGq/11KO mice showed no defects in the ability of the melanocortin agonist melanotan II to acutely stimulate energy expenditure or to inhibit food intake.
    1 context sentence
    Summary · context
    Mice with DMH-specific deletion of Gq/11α (DMHGq/11KO) were generated by stereotaxic injection of adeno-associated virus (AAV)-Cre-green fluorescent protein (GFP) into the DMH of Gqαflox/flox:G11α-/- mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with dorsomedial hypothalamus Gq/11alpha deletion, melanotan II still inhibited food intake, with no defect compared with controls.

    In plain wordsIn mice lacking Gq/11alpha in one brain area, melanotan II still reduced food intake as it did in control mice.

    Peptide
    Melanotan II
    Outcome
    No significant changeInhibition of food intake by melanotan II
    Study

    mousen: not reported in source

    Mice with dorsomedial hypothalamus deletion of Gq/11alpha (DMHGq/11KO)
    Comparator
    Control mice with AAV-GFP
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DMHGq/11KO mice showed no defects in the ability of the melanocortin agonist melanotan II to acutely stimulate energy expenditure or to inhibit food intake.
    1 context sentence
    Summary · context
    Mice with DMH-specific deletion of Gq/11α (DMHGq/11KO) were generated by stereotaxic injection of adeno-associated virus (AAV)-Cre-green fluorescent protein (GFP) into the DMH of Gqαflox/flox:G11α-/- mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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