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Study · Animal study (in vivo) · rat · 2017

4 results

Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction.

Côté I, Sakarya Y, Kirichenko N, Morgan D, Carter CS, Tümer N, Scarpace PJ

Canadian journal of physiology and pharmacology19 Oct 2016Cited by 3 (Europe PMC)

PMID28051332 (opens in a new tab)PMCIDPMC5572812 (opens in a new tab)DOI10.1139/cjpp-2016-0290 (opens in a new tab)PepBankPUB-28051332
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, central MTII infusion suppressed appetite in a dose-dependent manner.

    In plain wordsIn rats, MTII infused into the brain lowered appetite, and the higher dose lowered it more.

    Peptide
    Melanotan II
    Outcome
    DecreaseAppetite suppression
    Study

    ratn: not reported in source

    6-month-old F344BN rats
    Comparator
    aCSF
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular infusion (lateral ventricle) · 40 daysAs given in this study (rat).

    Source sentences

    Summary
    MTII suppressed appetite in a dose-dependent manner (P < 0.05).
    1 context sentence
    Summary · context
    MTII (high or low dose) or artificial cerebrospinal fluid (aCSF) was infused into the lateral ventricle of the brain of 6-month-old F344BN rats (6-7/group) over 40 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, food intake on MTII promptly rose back to the control level.

    In plain wordsIn rats, food intake on MTII returned quickly to the level of control rats.

    Peptide
    Melanotan II
    Outcome
    No significant changeFood intake after initial suppression
    Study

    ratn: not reported in source

    6-month-old F344BN rats
    Comparator
    aCSF
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular infusion (lateral ventricle) · 40 daysAs given in this study (rat).

    Source sentences

    Summary
    Although food intake promptly rose back to control level
    1 context sentence
    Summary · context
    MTII (high or low dose) or artificial cerebrospinal fluid (aCSF) was infused into the lateral ventricle of the brain of 6-month-old F344BN rats (6-7/group) over 40 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, body mass was persistently reduced in both MTII dose groups compared with aCSF.

    In plain wordsIn rats, MTII infused into the brain kept body mass lower than in control rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody mass
    Study

    ratn: not reported in source

    6-month-old F344BN rats
    Comparator
    aCSF
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular infusion (lateral ventricle) · 40 daysAs given in this study (rat).

    Source sentences

    Summary
    body mass was persistently reduced in both MTII groups (P < 0.01).
    1 context sentence
    Summary · context
    MTII (high or low dose) or artificial cerebrospinal fluid (aCSF) was infused into the lateral ventricle of the brain of 6-month-old F344BN rats (6-7/group) over 40 days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    At day 40, both MTII groups had lower adiposity than aCSF rats.

    In plain wordsIn rats, after 40 days of MTII, body fat was lower than in control rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseAdiposity at day 40
    Study

    ratn: not reported in source

    6-month-old F344BN rats
    Comparator
    aCSF
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular infusion (lateral ventricle) · 40 daysAs given in this study (rat).

    Source sentences

    Summary
    At day 40, both MTII groups displayed lower adiposity than the aCSF animals (P < 0.01).
    1 context sentence
    Summary · context
    MTII (high or low dose) or artificial cerebrospinal fluid (aCSF) was infused into the lateral ventricle of the brain of 6-month-old F344BN rats (6-7/group) over 40 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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