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Study · Animal study (in vivo) · zebrafish · 2023

3 results

Melanotan-II reverses memory impairment induced by a short-term HF diet.

Wekwejt P, Wojda U, Kiryk A

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie19 Jul 2023Cited by 1 (Europe PMC)

PMID37478579 (opens in a new tab)DOI10.1016/j.biopha.2023.115129 (opens in a new tab)PepBankPUB-37478579
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish fed a high-fat diet, MT-II reversed the impairment of recognition memory, which became similar to that of the control group.

    In plain wordsIn zebrafish fed a high-fat diet, MT-II restored recognition memory to a level similar to fish on the control diet.

    Peptide
    Melanotan II
    Outcome
    IncreaseRecognition memory
    Study

    zebrafishn: not reported in source

    Zebrafish fed a high-fat diet
    Comparator
    High-fat diet without MT-II
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Animals fed a HF diet and treated with MT-II demonstrated recognition memory, anxiety, and exploratory behavior similar to the control group.
    2 context sentences
    Summary · context
    These HF diet-induced abnormalities were reversed by MT-II.
    Summary · context
    Zebrafish fed the HF diet showed an impairment in recognition memory, elevated anxiety levels, and reduced exploratory propensity after just three weeks compared to zebrafish fed the control diet.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish fed a high-fat diet, MT-II reversed the elevated anxiety levels, which became similar to those of the control group.

    In plain wordsIn zebrafish fed a high-fat diet, MT-II brought anxiety back to a level similar to fish on the control diet.

    Peptide
    Melanotan II
    Outcome
    DecreaseAnxiety
    Study

    zebrafishn: not reported in source

    Zebrafish fed a high-fat diet
    Comparator
    High-fat diet without MT-II
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Animals fed a HF diet and treated with MT-II demonstrated recognition memory, anxiety, and exploratory behavior similar to the control group.
    2 context sentences
    Summary · context
    These HF diet-induced abnormalities were reversed by MT-II.
    Summary · context
    Zebrafish fed the HF diet showed an impairment in recognition memory, elevated anxiety levels, and reduced exploratory propensity after just three weeks compared to zebrafish fed the control diet.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish fed a high-fat diet, MT-II reversed the reduced exploratory propensity, which became similar to that of the control group.

    In plain wordsIn zebrafish fed a high-fat diet, MT-II brought exploring behavior back to a level similar to fish on the control diet.

    Peptide
    Melanotan II
    Outcome
    IncreaseExploratory behavior
    Study

    zebrafishn: not reported in source

    Zebrafish fed a high-fat diet
    Comparator
    High-fat diet without MT-II
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Animals fed a HF diet and treated with MT-II demonstrated recognition memory, anxiety, and exploratory behavior similar to the control group.
    2 context sentences
    Summary · context
    These HF diet-induced abnormalities were reversed by MT-II.
    Summary · context
    Zebrafish fed the HF diet showed an impairment in recognition memory, elevated anxiety levels, and reduced exploratory propensity after just three weeks compared to zebrafish fed the control diet.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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