In rats with a sciatic nerve crush, the non-selective melanocortin agonist melanotan II accelerated sensory recovery, whereas the MC4-selective peptides did not.
In plain wordsIn rats with a crushed sciatic nerve, melanotan II sped up recovery of sensation, while two MC4-selective peptides did not.
- Peptide
- Melanotan II
- Outcome
- IncreaseSensory recovery after sciatic nerve crush
- Study
ratn: not reported in source
Rat sciatic nerve crush- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
Both peptides did not accelerate sensory recovery in rats with a sciatic nerve crush, whereas the non-selective melanocortin agonist melanotan-II (MTII, Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]NH2) was effective.
1 context sentence(design, population, supporting numbers)
To test whether the melanocortin MC4 receptor is involved in the effects of melanocortins on functional recovery, we used melanocortin compounds that distinguish the melanocortin MC4 receptor from the melanocortin MC1, MC3 and MC5 receptors on basis of selectivity and agonist/antagonist profile.