Food deprivation decreases responsiveness of ventromedial hypothalamic neurons to melanocortins.

Li YZ, Davidowa H

Journal of neuroscience research1 Aug 2004Cited by 14 (Europe PMC)

PMID15264229DOI10.1002/jnr.20192PepBankPUB-15264229

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In brain slices, fewer ventromedial hypothalamic neurons from food-deprived rats responded to the highest MTII dose than neurons from fed rats.
In plain wordsIn lab tests on rat brain slices, fewer neurons from food-deprived rats responded to MTII than neurons from fed rats.
Peptide
Melanotan II
Outcome
DecreaseProportion of VMH neurons responding to the highest MTII dose
Study
ratn: not reported in source
Brain slices of ventromedial hypothalamic neurons from fed and food-deprived rats
Comparator
Fed rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
highest dose testedAs given in this study (rat).
Measurements
Responding neurons
61%
fed rats
Responding neurons
33%
food-deprived rats
Source sentences
Summary
Responses to the highest dose MTII were observed in 61% of VMH neurons from fed rats but only 33% of VMH neurons from food-deprived rats.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this question, responses of ventromedial hypothalamic (VMH) neurons to melanotan II (MTII; a synthetic analogue of alpha-MSH) were recorded in brain slices from fed and food-deprived rats.
Report a problemFND-1526422901

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

02LabNot a test of Melanotan II aloneEx vivo tissueActivity measurement
In brain slices, AGRP significantly reduced the responsiveness of ventromedial hypothalamic neurons to MTII.
In plain wordsIn lab tests on rat brain slices, AGRP reduced how strongly neurons responded to MTII.
Peptide
Melanotan II
Outcome
DecreaseVMH neuron responsiveness to MTII with AGRP
Study
ratn: not reported in source
Brain slices of ventromedial hypothalamic neurons from fed and food-deprived rats
Comparator
MTII alone
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
AGRP significantly reduced VMH responsiveness to MTII.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this question, responses of ventromedial hypothalamic (VMH) neurons to melanotan II (MTII; a synthetic analogue of alpha-MSH) were recorded in brain slices from fed and food-deprived rats.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-1526422902
03LabNot a test of Melanotan II aloneEx vivo tissueActivity measurement
In brain slices, with AGRP present, MTII significantly inhibited neuronal activity in food-deprived rats but not in fed rats.
In plain wordsIn lab tests on rat brain slices, with AGRP present MTII inhibited neurons from food-deprived rats but not from fed rats.
Peptide
Melanotan II
Outcome
MixedVMH neuron activity with MTII in the presence of AGRP
Study
ratn: not reported in source
Brain slices of ventromedial hypothalamic neurons from fed and food-deprived rats
Comparator
Fed rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
In the presence of AGRP, MTII induced a significant inhibition of neuronal activity in deprived rats, but not in fed rats.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this question, responses of ventromedial hypothalamic (VMH) neurons to melanotan II (MTII; a synthetic analogue of alpha-MSH) were recorded in brain slices from fed and food-deprived rats.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-1526422903

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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