[Energy homeostasis regulated by an adipocyte-derived hormone--mechanism of leptin resistance and role of hypothalamic melanocortin signaling].

Masuzaki H, Tanaka T, Ebihara K, Hosoda K, Nakao K

Nihon rinsho. Japanese journal of clinical medicine1 Feb 2009Cited by 1 (Europe PMC)

PMID19202901PepBankPUB-19202901

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, intracerebroventricular administration of the melanocortin agonist MT-II overcame high fat diet-induced leptin resistance.
In plain wordsIn mice, MT-II given into the brain overcame resistance to the hormone leptin caused by a high fat diet.
Peptide
Melanotan II
Outcome
DecreaseHigh fat diet-induced leptin resistance
Study
mousen: not reported in source
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Actually, intracerebroventricular administration of melanocortin agonist MT-II robustly overcomes high fat diet-induced leptin resistance
1 context sentence(design, population, supporting numbers)
Summary · context
In an attempt to elucidate underlying mechanism of leptin resistance in obesity, we found that the activity of skeletal muscle AMP-activated protein kinase (AMPK) tightly parallels hypothalamic leptin sensitivity and metabolic phenotype in transgenic mice overexpressing leptin.
Report a problemFND-1920290101
02AnimalAnimal study (in vivo)Efficacy outcome
In mice, intracerebroventricular MT-II ameliorated high fat diet-related hyperphagia.
In plain wordsIn mice, MT-II given into the brain reduced overeating caused by a high fat diet.
Peptide
Melanotan II
Outcome
DecreaseHyperphagia
Study
mousen: not reported in source
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Actually, intracerebroventricular administration of melanocortin agonist MT-II
2 context sentences(design, population, supporting numbers)
Summary · context
ameliorates fuel dyshomeostasis and hyperphagia in mice, with a concomitant recovery of AMPK activity in skeletal muscle, thereby highlighting the system as a therapeutic target for leptin resistance.
Summary · context
In an attempt to elucidate underlying mechanism of leptin resistance in obesity, we found that the activity of skeletal muscle AMP-activated protein kinase (AMPK) tightly parallels hypothalamic leptin sensitivity and metabolic phenotype in transgenic mice overexpressing leptin.
Report a problemFND-1920290102
03AnimalAnimal study (in vivo)Efficacy outcome
In mice, intracerebroventricular MT-II ameliorated fuel dyshomeostasis in high fat diet-induced leptin resistance.
In plain wordsIn mice, MT-II given into the brain improved the body's handling of fuel after a high fat diet.
Peptide
Melanotan II
Outcome
DecreaseFuel dyshomeostasis
Study
mousen: not reported in source
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Actually, intracerebroventricular administration of melanocortin agonist MT-II
2 context sentences(design, population, supporting numbers)
Summary · context
ameliorates fuel dyshomeostasis and hyperphagia in mice, with a concomitant recovery of AMPK activity in skeletal muscle, thereby highlighting the system as a therapeutic target for leptin resistance.
Summary · context
In an attempt to elucidate underlying mechanism of leptin resistance in obesity, we found that the activity of skeletal muscle AMP-activated protein kinase (AMPK) tightly parallels hypothalamic leptin sensitivity and metabolic phenotype in transgenic mice overexpressing leptin.
Report a problemFND-1920290103
04AnimalAnimal study (in vivo)Efficacy outcome
In mice, intracerebroventricular MT-II was accompanied by recovery of AMPK activity in skeletal muscle.
In plain wordsIn mice, MT-II given into the brain was accompanied by recovery of an energy-sensing enzyme in muscle.
Peptide
Melanotan II
Outcome
IncreaseAMPK activity in skeletal muscle
Study
mousen: not reported in source
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Actually, intracerebroventricular administration of melanocortin agonist MT-II
2 context sentences(design, population, supporting numbers)
Summary · context
with a concomitant recovery of AMPK activity in skeletal muscle, thereby highlighting the system as a therapeutic target for leptin resistance.
Summary · context
In an attempt to elucidate underlying mechanism of leptin resistance in obesity, we found that the activity of skeletal muscle AMP-activated protein kinase (AMPK) tightly parallels hypothalamic leptin sensitivity and metabolic phenotype in transgenic mice overexpressing leptin.
Report a problemFND-1920290104

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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