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Study · Ex vivo tissue · rat · 2000

2 results

Regulation of neuropeptide Y release from hypothalamic slices by melanocortin-4 agonists and leptin.

King PJ, Widdowson PS, Doods H, Williams G

Peptides1 Jan 2000Cited by 17 (Europe PMC)

PMID10704718 (opens in a new tab)DOI10.1016/s0196-9781(99)00168-0 (opens in a new tab)PepBankPUB-10704718
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat hypothalamic slices, MT-II significantly inhibited potassium-stimulated NPY release.

    In plain wordsIn rat brain tissue slices, melanotan II reduced stimulated release of the appetite-raising signal NPY.

    Peptide
    Melanotan II
    Outcome
    DecreasePotassium-stimulated NPY release
    Study

    ratn: not reported in source

    hypothalamic slices
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the melanocortin-4 agonists, alpha-MSH and MT-II, significantly inhibited potassium-stimulated NPY release (p < 0.01)
    1 context sentence
    Summary · context
    We have examined the regulation of the orexigenic neurotransmitter, NPY, in hypothalamic slices of rat brain to discover whether the leptin or melanocortin receptor-4 (MCR-4) agonists, which act as satiety signals, can influence the release of this neurotransmitter.
  2. 02LabEx vivo tissueMechanism

    In rat hypothalamic slices, MT-II did not significantly alter basal NPY release.

    In plain wordsIn rat brain tissue slices, melanotan II did not change resting release of the signal NPY.

    Peptide
    Melanotan II
    Outcome
    No significant changeBasal NPY release
    Study

    ratn: not reported in source

    hypothalamic slices
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    without significantly altering basal NPY release.
    1 context sentence
    Summary · context
    We have examined the regulation of the orexigenic neurotransmitter, NPY, in hypothalamic slices of rat brain to discover whether the leptin or melanocortin receptor-4 (MCR-4) agonists, which act as satiety signals, can influence the release of this neurotransmitter.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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