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Study · Animal study (in vivo) · mouse and rat · 2007

7 results

The effects of the melanocortin agonist (MT-II) on subcutaneous and visceral adipose tissue in rodents.

Strader AD, Shi H, Ogawa R, Seeley RJ, Reizes O

The Journal of pharmacology and experimental therapeutics13 Jun 2007Cited by 5 (Europe PMC)

PMID17567964 (opens in a new tab)DOI10.1124/jpet.107.123091 (opens in a new tab)PepBankPUB-17567964
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diet-induced obese mice, melanotan II treatment reduced body weight.

    In plain wordsIn obese mice, melanotan II caused weight loss.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight in DIO mice
    Study

    mousen: not reported in source

    high-fat diet-induced obese mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MT-II-treated high-fat diet-induced obese (DIO) mice lost weight and body fat
    1 context sentence
    Summary · context
    In this study, we analyzed the peripheral effects of the synthetic melanocortin agonist melanotan-II (MT-II) in rodents fed a low-fat or high-fat diet.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diet-induced obese mice, melanotan II treatment reduced body fat.

    In plain wordsIn obese mice, melanotan II reduced body fat.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody fat in DIO mice
    Study

    mousen: not reported in source

    high-fat diet-induced obese mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MT-II-treated high-fat diet-induced obese (DIO) mice lost weight and body fat
    1 context sentence
    Summary · context
    In this study, we analyzed the peripheral effects of the synthetic melanocortin agonist melanotan-II (MT-II) in rodents fed a low-fat or high-fat diet.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In low-fat-fed mice, melanotan II treatment did not change body weight.

    In plain wordsIn mice on a low-fat diet, melanotan II did not change body weight.

    Peptide
    Melanotan II
    Outcome
    No significant changeBody weight in low-fat-fed mice
    Study

    mousen: not reported in source

    low-fat-fed mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MT-II-treated low-fat-fed mice maintained their original body weight.
    1 context sentence
    Summary · context
    In this study, we analyzed the peripheral effects of the synthetic melanocortin agonist melanotan-II (MT-II) in rodents fed a low-fat or high-fat diet.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In high-fat-fed mice, melanotan II reduced both visceral and subcutaneous adipose tissue compared with ad libitum vehicle controls.

    In plain wordsIn high-fat-fed mice, melanotan II reduced both belly and under-skin fat compared with vehicle-treated mice that ate freely.

    Peptide
    Melanotan II
    Outcome
    DecreaseVisceral and subcutaneous adipose tissue versus vehicle
    Study

    mousen: not reported in source

    high-fat-fed mice
    Comparator
    Vehicle (ad libitum) controls
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, MT-II treatment led to a general reduction in both visceral and subcutaneous adipose tissue in high-fat-fed mice compared with Vehicle (ad libitum) controls.
    1 context sentence
    Summary · context
    In this study, we analyzed the peripheral effects of the synthetic melanocortin agonist melanotan-II (MT-II) in rodents fed a low-fat or high-fat diet.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In diet-induced obese mice, vehicle-treated pair-fed mice lost an equivalent amount of body weight as melanotan II-treated mice.

    In plain wordsIn obese mice, melanotan II and pair-feeding gave the same weight loss.

    Peptide
    Melanotan II
    Outcome
    No significant changeBody weight versus pair-fed vehicle mice
    Study

    mousen: not reported in source

    DIO mice
    Comparator
    Vehicle-treated pair-fed mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vehicle-treated pair-fed DIO mice lost an equivalent amount of body weight compared with MT-II-treated mice but retained more adipose tissue.
    1 context sentence
    Summary · context
    In this study, we analyzed the peripheral effects of the synthetic melanocortin agonist melanotan-II (MT-II) in rodents fed a low-fat or high-fat diet.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In diet-induced obese mice, melanotan II-treated mice lost more adipose tissue than pair-fed vehicle mice with equal weight loss.

    In plain wordsIn obese mice with equal weight loss, melanotan II reduced body fat more than pair-feeding did.

    Peptide
    Melanotan II
    Outcome
    DecreaseAdipose tissue versus pair-fed vehicle mice
    Study

    mousen: not reported in source

    DIO mice
    Comparator
    Vehicle-treated pair-fed mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vehicle-treated pair-fed DIO mice lost an equivalent amount of body weight compared with MT-II-treated mice but retained more adipose tissue.
    1 context sentence
    Summary · context
    In this study, we analyzed the peripheral effects of the synthetic melanocortin agonist melanotan-II (MT-II) in rodents fed a low-fat or high-fat diet.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In diet-induced obese rats, melanotan II treatment led to a generalized reduction in adipose tissue.

    In plain wordsIn obese rats, melanotan II reduced fat tissue across the body.

    Peptide
    Melanotan II
    Outcome
    DecreaseAdipose tissue in DIO rats
    Study

    ratn: not reported in source

    diet-induced obese rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The data were replicated in DIO rats and indicated that MT-II treatment led to a generalized reduction in adipose tissue.
    1 context sentence
    Summary · context
    In this study, we analyzed the peripheral effects of the synthetic melanocortin agonist melanotan-II (MT-II) in rodents fed a low-fat or high-fat diet.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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