In mouse brain stem slices, melanotan II did not excite PPG neurons in the nucleus tractus solitarius, whereas CCK and epinephrine did.
In plain wordsIn mouse brain slices, melanotan II did not excite PPG neurons, but CCK and epinephrine did.
- Peptide
- Melanotan II
- Outcome
- No significant changeExcitation of NTS-PPG neurons by melanotan II
- Study
mousen: not reported in source
brain stem slices with PPG neurons- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
PPG neurons in the NTS were excited by CCK and epinephrine, but not by the melanocortin receptor agonist melanotan II.
1 context sentence(design, population, supporting numbers)
Transgenic mice expressing yellow fluorescent protein (Venus) under the control of the PPG promoter were used to identify PPG neurons in vitro and to record their electrical and pharmacological profile.