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Study · Ex vivo tissue · mouse · 2017

2 results

AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting.

Gupta R, Ma Y, Wang M, Whim MD

Endocrinology1 Aug 2017Cited by 24 (Europe PMC)

PMID28531318 (opens in a new tab)PMCIDPMC5551550 (opens in a new tab)DOI10.1210/en.2016-1268 (opens in a new tab)PepBankPUB-28531318
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    Melanotan II decreased the paired-pulse ratio of evoked synaptic currents recorded in adrenal chromaffin cells, and exogenous AgRP blocked this effect.

    In plain wordsIn mouse adrenal tissue, melanotan II changed nerve signalling onto adrenal cells, and AgRP blocked this change.

    Peptide
    Melanotan II
    Outcome
    DecreasePaired-pulse ratio of evoked synaptic currents in chromaffin cells
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Melanotan II decreased the paired-pulse ratio of evoked synaptic currents recorded in chromaffin cells; this effect was blocked by exogenous AgRP.
  2. 02LabIn vitro (cells)Mechanism

    Melanotan II did not alter optogenetically evoked release of catecholamines from isolated chromaffin cells.

    In plain wordsIn isolated mouse adrenal cells, melanotan II did not change the release of adrenaline-type hormones.

    Peptide
    Melanotan II
    Outcome
    No significant changeOptogenetically evoked catecholamine release from isolated chromaffin cells
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, neither melanotan II nor AgRP altered the optogenetically evoked release of catecholamines from isolated chromaffin cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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