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Study · Animal study (in vivo) · rat · 2023

2 results

Evidence for a feeding related association between melanocortin in the NTS and Neuropeptide-Y in the PVN.

Kim EM, Quinn JG, Reid RE, O'Hare E

Appetite29 May 2023Cited by 4 (Europe PMC)

PMID37257508 (opens in a new tab)DOI10.1016/j.appet.2023.106618 (opens in a new tab)PepBankPUB-37257508
Publisher pagePubMedAsk about this study
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Summary

Melanocortin and neuropeptide-Y (NPY) are both involved in feeding and energy regulation, and they have opposite effects in the paraventricular nucleus of the hypothalamus (PVN). The present study examined an interaction between melanocortin in the nucleus of the solitary tract (NTS) and NPY in the PVN. Male Sprague-Dawley rats were implanted with cannulae in the injection sites of interest. In Experiment 1, subjects received either the melanocortin 3/4-receptor (MC3/4) antagonist SHU9119 (0, 10, 50 and 100 pmol/0.5 μl) or the MC3/4 agonist MTII (0, 10, 50, 100 and 200 pmol/0.5 μl) into the NTS. Food intake was measured at 1, 2, 4, 6 and 24-h post-injection. Administration of SHU9119 into the NTS significantly and dose-dependently increased food intake at 1, 2, 4, 6 and 6-24-h, and administration of MTII into the NTS significantly and dose-dependently decreased 24-h free feeding. In Experiment 2, subjects received the MC3/4 agonist MTII (0, 10, 50, 100 and 200 pmol/0.5 μl) into the NTS just prior to NPY (0 and 1μg/0.5 μl) in the PVN. PVN injection of NPY stimulated feeding, and administration of MTII (50, 100 and 200 pmol) into the NTS significantly and dose-dependently decreased NPY-induced feeding at 2, 4, 6 and 6-24-h. These data suggest that there could be a neuronal association between melanocortin in the NTS and NPY in the PVN, and that the melanocortin system in the NTS has an antagonistic effect on NPY-induced feeding in the PVN.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MTII injected into the nucleus of the solitary tract dose-dependently decreased 24-h free feeding.

    In plain wordsIn rats, MTII injected into a brain region called the NTS reduced 24-hour feeding, and larger doses reduced it more.

    Peptide
    Melanotan II
    Outcome
    Decrease24-h free feeding
    Study

    ratn: not reported in source

    Male Sprague-Dawley rats with cannulae in the nucleus of the solitary tract and paraventricular nucleus
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    10-200 pmol/0.5 μl · injection into the nucleus of the solitary tractAs given in this study (rat).

    Source sentences

    Summary
    administration of MTII into the NTS significantly and dose-dependently decreased 24-h free feeding.
    2 context sentences
    Summary · context
    In Experiment 1, subjects received either the melanocortin 3/4-receptor (MC3/4) antagonist SHU9119 (0, 10, 50 and 100 pmol/0.5 μl) or the MC3/4 agonist MTII (0, 10, 50, 100 and 200 pmol/0.5 μl) into the NTS.
    Summary · context
    Male Sprague-Dawley rats were implanted with cannulae in the injection sites of interest.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MTII in the nucleus of the solitary tract dose-dependently decreased feeding induced by NPY in the paraventricular nucleus.

    In plain wordsIn rats, MTII in the NTS reduced the extra feeding caused by NPY, and larger doses reduced it more.

    Peptide
    Melanotan II
    Outcome
    DecreaseNPY-induced feeding
    Study

    ratn: not reported in source

    Male Sprague-Dawley rats with cannulae in the nucleus of the solitary tract and paraventricular nucleus
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    50-200 pmol/0.5 μl · injection into the nucleus of the solitary tractAs given in this study (rat).

    Source sentences

    Summary
    PVN injection of NPY stimulated feeding, and administration of MTII (50, 100 and 200 pmol) into the NTS significantly and dose-dependently decreased NPY-induced feeding at 2, 4, 6 and 6-24-h.
    2 context sentences
    Summary · context
    In Experiment 2, subjects received the MC3/4 agonist MTII (0, 10, 50, 100 and 200 pmol/0.5 μl) into the NTS just prior to NPY (0 and 1μg/0.5 μl) in the PVN.
    Summary · context
    Male Sprague-Dawley rats were implanted with cannulae in the injection sites of interest.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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