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Study · Animal study (in vivo) · rat · 2024

3 results

Multiple metabolic signals in the CeA regulate feeding: The role of AMPK.

Castro G, Mendes NF, Weissmann L, Quaresma PGF, Saad MJA, Prada PO

Molecular and cellular endocrinology10 Apr 2024

PMID38604549 (opens in a new tab)DOI10.1016/j.mce.2024.112232 (opens in a new tab)PepBankPUB-38604549
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, chronic injection of melanotan II into the central amygdala reduced body mass over seven days.

    In plain wordsIn rats, melanotan II injected into the amygdala lowered body weight over seven days.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody mass
    Study

    ratn: not reported in source

    Wistar rats with cannula in the central nucleus of the amygdala
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · injection into the central nucleus of the amygdala · seven daysAs given in this study (rat).

    Source sentences

    Summary
    chronic injection of Melanotan II (MTII) in CeA reduced body mass and food intake over seven days together with a slight decrease in AMPKThr172.
    1 context sentence
    Summary · context
    On a chow diet, eight-week-old Wistar male rats were stereotaxically implanted with a cannula in the CeA to inject several modulators of AMPKα1/2Thr172 phosphorylation, and we performed physiological and molecular assays.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, chronic injection of melanotan II into the central amygdala reduced food intake over seven days.

    In plain wordsIn rats, melanotan II injected into the amygdala reduced food intake over seven days.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake
    Study

    ratn: not reported in source

    Wistar rats with cannula in the central nucleus of the amygdala
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · injection into the central nucleus of the amygdala · seven daysAs given in this study (rat).

    Source sentences

    Summary
    chronic injection of Melanotan II (MTII) in CeA reduced body mass and food intake over seven days together with a slight decrease in AMPKThr172.
    1 context sentence
    Summary · context
    On a chow diet, eight-week-old Wistar male rats were stereotaxically implanted with a cannula in the CeA to inject several modulators of AMPKα1/2Thr172 phosphorylation, and we performed physiological and molecular assays.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, chronic injection of melanotan II into the central amygdala was accompanied by a slight decrease in AMPKThr172.

    In plain wordsIn rats, melanotan II in the amygdala came with a slight drop in the energy-sensor protein AMPK activation.

    Peptide
    Melanotan II
    Outcome
    DecreaseAMPK Thr172 phosphorylation in the central amygdala
    Study

    ratn: not reported in source

    Wistar rats with cannula in the central nucleus of the amygdala
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · injection into the central nucleus of the amygdala · seven daysAs given in this study (rat).

    Source sentences

    Summary
    chronic injection of Melanotan II (MTII) in CeA reduced body mass and food intake over seven days together with a slight decrease in AMPKThr172.
    1 context sentence
    Summary · context
    On a chow diet, eight-week-old Wistar male rats were stereotaxically implanted with a cannula in the CeA to inject several modulators of AMPKα1/2Thr172 phosphorylation, and we performed physiological and molecular assays.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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