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Study · Animal study (in vivo) · rat · 2003

1 result

Evaluation of the role of melanocortin 3 and 4 receptors in leptin-stimulated and spontaneous growth hormone secretion in rats.

Watanobe H, Yoneda M

Neuroendocrinology1 Dec 2003Cited by 5 (Europe PMC)

PMID14688446 (opens in a new tab)DOI10.1159/000074886 (opens in a new tab)PepBankPUB-14688446
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In fasted male rats, melanotan II (1.0 nmol) did not significantly change growth hormone release.

    In plain wordsIn fasted rats, melanotan II did not change growth hormone release.

    Peptide
    Melanotan II
    Outcome
    No significant changeGrowth hormone release in fasted rats
    Study

    ratn: not reported in source

    Comparator
    Vehicle
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.0 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    neither melanotan-II (1.0 nmol, a non-selective MC3/4-R agonist) nor gamma(1)-melanocyte-stimulating hormone (10 nmol, a selective MC3-R agonist) affected significantly GH release in fasted rats.
    1 context sentence
    Summary · context
    In both fed and 3-day fasted rats, plasma GH levels were determined every 15 min over 5 h after single intracerebroventricular injections of the following substances or vehicle.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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