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Study · Animal study (in vivo) · 2014

6 results

Profound and rapid reduction in body temperature induced by the melanocortin receptor agonists.

Xu Y, Kim ER, Fan S, Xia Y, Xu Y, Huang C, Tong Q

Biochemical and biophysical research communications24 Jul 2014Cited by 8 (Europe PMC)

PMID25065745 (opens in a new tab)PMCIDPMC4162093 (opens in a new tab)DOI10.1016/j.bbrc.2014.07.079 (opens in a new tab)PepBankPUB-25065745
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    Intraperitoneal MTII caused a rapid reduction in body temperature in animals.

    In plain wordsIn animals, MTII given by injection into the abdomen quickly lowered body temperature.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody temperature
    Study

    n: not reported in source

    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    Unexpectedly, we observed that intraperitoneal (i.p.) administration of MTII induced a rapid reduction in both body temperature and energy expenditure
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    Intraperitoneal MTII caused a rapid reduction in energy expenditure that was independent of its effect on feeding.

    In plain wordsIn animals, MTII quickly lowered energy expenditure, and this did not depend on its effect on eating.

    Peptide
    Melanotan II
    Outcome
    DecreaseEnergy expenditure, rapid phase
    Study

    n: not reported in source

    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    Unexpectedly, we observed that intraperitoneal (i.p.) administration of MTII induced a rapid reduction in both body temperature and energy expenditure, which was independent of its effect on feeding and followed by a prolonged increase in energy expenditure.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    The rapid reduction after intraperitoneal MTII was followed by a prolonged increase in energy expenditure.

    In plain wordsIn animals, after the quick drop, MTII caused a longer rise in energy expenditure.

    Peptide
    Melanotan II
    Outcome
    IncreaseEnergy expenditure, prolonged phase
    Study

    n: not reported in source

    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    which was independent of its effect on feeding and followed by a prolonged increase in energy expenditure.
  4. 04AnimalAnimal study (in vivo)Mechanism

    The body temperature-lowering effect of MTII did not require the presence of MC4Rs.

    In plain wordsIn animals, MTII lowered body temperature even without the MC4 receptor.

    Peptide
    Melanotan II
    Outcome
    DecreaseMC4R dependence of the body temperature fall
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    In addition, the body temperature-lowering effect of MTII was independent of the presence of MC4Rs, but in a similar fashion to the previously shown effect on body temperature by 5'AMP.
  5. 05AnimalAnimal study (in vivo)Mechanism

    Beta-adrenergic receptors were required for recovery from the low body temperature that MTII induced.

    In plain wordsIn animals, recovery from the low body temperature that MTII caused needed beta-adrenergic receptors.

    Peptide
    Melanotan II
    Outcome
    Not applicableRole of beta-adrenergic receptors in recovery from MTII-induced low body temperature
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    β-adrenergic receptors (β-ARs) were required for the recovery from low body temperature induced by MTII
  6. 06AnimalAnimal study (in vivo)Mechanism

    Pharmacological studies indicated that the effect of MTII on body temperature may be partially mediated by vasopressin V1a receptors.

    In plain wordsIn animals, vasopressin V1a receptors may partly explain how MTII lowers body temperature.

    Peptide
    Melanotan II
    Outcome
    Not applicableRole of vasopressin V1a receptors in the MTII body temperature effect
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    further pharmacological studies showed that the MTII's effect on body temperature may be partially mediated by the vasopressin V1a receptors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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