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Study · Animal study (in vivo) · rat · 1994

3 results

Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide.

Lan EL, Ugwu SO, Blanchard J, Fang X, Hruby VJ, Sharma S

Journal of pharmaceutical sciences1 Aug 1994Cited by 8 (Europe PMC)

PMID7983590 (opens in a new tab)DOI10.1002/jps.2600830805 (opens in a new tab)PepBankPUB-07983590
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, melanotan II had a bioavailability of 4.6%.

    In plain wordsIn rats, 4.6 percent of melanotan II reached the blood in the bioavailability study.

    Peptide
    Melanotan II
    Outcome
    Not applicableBioavailability in rat
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Bioavailability
    4.6%
    rat

    Source sentences

    Summary
    the observance of a bioavailability of 4.6% in the rat, indicate that 1 may be a suitable candidate for oral delivery.

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 02LabNot a test of Melanotan II aloneIn vitro (cell-free)Other

    The pKa values of melanotan II were estimated at 6.54 (histidine) and 11.72 (arginine).

    In plain wordsIn lab tests, melanotan II had two measured acid-base constants, 6.54 for histidine and 11.72 for arginine.

    Peptide
    Melanotan II
    Outcome
    Not applicableDissociation constants
    Study

    n: not reported in source

    Potentiometric titration and UV spectrophotometry
    Outcome group
    Analytical methods and detection · Pharmacology

    Measurements

    pKa1 (histidine)
    6.54 pKa
    melanotan-II
    pKa2 (arginine)
    11.72 pKa
    melanotan-II

    Source sentences

    Summary
    The pKa1 (histidine) and pKa2 (arginine) were estimated to be 6.54 and 11.72, respectively.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

  2. 03LabNot a test of Melanotan II aloneIn vitro (cell-free)Other

    At pH 7.35, melanotan II had an octanol partition coefficient of 2.82 and a delta log PC of 1.05.

    In plain wordsIn lab tests, melanotan II showed a partition coefficient of 2.82 in octanol at pH 7.35.

    Peptide
    Melanotan II
    Outcome
    Not applicableApparent partition coefficient
    Study

    n: not reported in source

    n-octanol and isooctane partition
    Outcome group
    Analytical methods and detection · Pharmacology

    Measurements

    PC(octanol)
    2.82
    pH 7.35
    delta log PC
    1.05
    pH 7.35

    Source sentences

    Summary
    The PC(octanol) and delta log PC at pH 7.35 were 2.82 and 1.05, respectively.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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