Neuropeptides, including neuropeptide Y and melanocortins, mediate lipolysis in murine adipocytes.

Bradley RL, Mansfield JP, Maratos-Flier E

Obesity research1 Apr 2005Cited by 50 (Europe PMC)

PMID15897473DOI10.1038/oby.2005.73PepBankPUB-15897473

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In freshly isolated mouse adipocytes, MTII treatment gave virtually identical results to 3T3-L1 cells, with increased free fatty acid release.
In plain wordsIn fat cells taken from mice, MTII had almost the same effect as in lab-grown fat cells: more fatty acid release.
Peptide
Melanotan II
Outcome
IncreaseFree fatty acid release (lipolysis) in freshly isolated adipocytes
Study
mousen: not reported in source
freshly isolated mouse adipocytes
Comparator
Basal (no peptide)
Outcome group
Fat metabolism and adipogenesis · Metabolic and weight
Studied dose
100 nM · up to 2 hoursAs given in this study (mouse).
Source sentences
Summary
Similar treatment of freshly isolated mouse adipocytes showed virtually identical results.
1 context sentence(design, population, supporting numbers)
Summary · context
Fully differentiated 3T3-L1 adipocytes serum starved overnight in Dulbecco's modified Eagle medium containing 2% bovine serum albumin or freshly isolated mouse adipocytes were incubated for up to 2 hours in the absence and presence of 100 nM each of NPY, MCH, alpha-MSH, the melanocortin receptor ago…
Report a problemFND-1589747302
02LabIn vitro (cells)Efficacy outcome
In 3T3-L1 mouse adipocytes, 100 nM MTII increased free fatty acid release compared with basal release at 2 hours.
In plain wordsIn lab-grown mouse fat cells, MTII made the cells release more fatty acids than untreated cells.
Peptide
Melanotan II
Outcome
IncreaseFree fatty acid release (lipolysis) in 3T3-L1 adipocytes
Study
mousen: not reported in source
3T3-L1 adipocytes
Comparator
Basal (no peptide)
Outcome group
Fat metabolism and adipogenesis · Metabolic and weight
Studied dose
100 nM · up to 2 hoursAs given in this study (mouse).
Measurements
Free fatty acid release
0.238 nM
MTII at 2 hours
Free fatty acid release
0.024 nM
basal at 2 hours
Source sentences
Summary
whereas both alpha-MSH and MTII stimulated up to a 7-fold increase in free fatty acid release (MTII, 0.238 +/- 0.004 vs. basal, 0.024 +/- 0.002 nM at 2 hours
1 context sentence(design, population, supporting numbers)
Summary · context
Fully differentiated 3T3-L1 adipocytes serum starved overnight in Dulbecco's modified Eagle medium containing 2% bovine serum albumin or freshly isolated mouse adipocytes were incubated for up to 2 hours in the absence and presence of 100 nM each of NPY, MCH, alpha-MSH, the melanocortin receptor ago…
Report a problemFND-1589747301

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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