Skip to content

Study · Animal study (in vivo) · rat · 2007

2 results

Effects of ghrelin, corticotrophin-releasing hormone, and melanotan-II on food intake in rats with paraventricular nucleus lesions.

Wang J, Ling S, Usami T, Murata T, Narita K, Higuchi T

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association1 Nov 2007Cited by 8 (Europe PMC)

PMID18058602 (opens in a new tab)DOI10.1055/s-2007-984438 (opens in a new tab)PepBankPUB-18058602
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sham-operated rats fasted for 24 h, intracerebroventricular melanotan II decreased food intake.

    In plain wordsIn rats with sham surgery, melanotan II reduced food intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake after MT-II in sham-operated rats
    Study

    ratn: not reported in source

    rats with PVN lesions or sham surgery
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    MT-II decreased FI in sham-operated, but not in PVN-lesioned rats.
    1 context sentence
    Summary · context
    After bilateral electrolytic lesions of the PVN, rats were given ghrelin intraperitoneally (i. p.), or intracerebroventricular (i. c. v.) infusion of CRH or MT-II.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with paraventricular nucleus lesions, intracerebroventricular melanotan II did not decrease food intake.

    In plain wordsIn rats with brain lesions in the paraventricular nucleus, melanotan II did not reduce food intake.

    Peptide
    Melanotan II
    Outcome
    No significant changeFood intake after MT-II in PVN-lesioned rats
    Study

    ratn: not reported in source

    rats with PVN lesions or sham surgery
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    MT-II decreased FI in sham-operated, but not in PVN-lesioned rats.
    1 context sentence
    Summary · context
    After bilateral electrolytic lesions of the PVN, rats were given ghrelin intraperitoneally (i. p.), or intracerebroventricular (i. c. v.) infusion of CRH or MT-II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.