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Study · In vitro (cells) · 2001

1 result

Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor.

Haskell-Luevano C, Monck EK

Regulatory peptides1 May 2001Cited by 201 (Europe PMC)

PMID11257308 (opens in a new tab)DOI10.1016/s0167-0115(01)00234-8 (opens in a new tab)PepBankPUB-11257308
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    At a constitutively active MC4R, the EC50 value of MTII (with alpha-MSH and NDP-MSH) was identical to that at the wild-type receptor.

    In plain wordsIn lab tests, MTII (with two other melanocortin agonists) acted on the engineered active receptor with the same potency as on the normal receptor.

    Peptide
    Melanotan II
    Outcome
    No significant changeAgonist EC50 at constitutively active MC4R versus wild-type MC4R
    Study

    n: not reported in source

    constitutively active MC4R
    Comparator
    Wild-type MC4R
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A constitutively active MC4R has been generated which possess EC(50) values for melanocortin agonists (alpha-MSH, NDP-MSH, and MTII) and a pA2 value for the synthetic peptide antagonist SHU9119 identical to the wildtype receptor

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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