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Study · Animal study (in vivo) · chicken · 2017

3 results

Modulatory function of NMDA glutamate receptor on MC3/MC4 receptors agonist-induced hypophagia in neonatal meat-type chicken.

Ahmadi F, Zendehdel M, Babapour V, Panahi N, Hassanpour S, Khodadadi M

Veterinary research communications6 Jun 2017Cited by 8 (Europe PMC)

PMID28589422 (opens in a new tab)DOI10.1007/s11259-017-9693-x (opens in a new tab)PepBankPUB-28589422
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal broiler chicks, intracerebroventricular MTII caused a dose-dependent decrease in food intake.

    In plain wordsIn chicks, MTII injected into the brain lowered food intake, and larger doses lowered it more.

    Peptide
    Melanotan II
    Outcome
    DecreaseCumulative food intake after ICV MTII
    Study

    chickenn: not reported in source

    Neonatal meat-type chicks, 3-h food-deprived
    Comparator
    Control solution
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    2.45, 4.8 and 9.8 pmol · intracerebroventricularAs given in this study (chicken).

    Source sentences

    Summary
    According to the results, dose dependent hypophagia observed after ICV injection of the MTII (p < 0.05).
    2 context sentences
    Summary · context
    In experiment 1, chickens were intracerebroventricular (ICV) injected with control solution, MTII (MC3/MC4 receptors agonist; 2.45, 4.8 and 9.8 pmol).
    Summary · context
    So, the aim of the current study was to determine the role of MC3/MC4 receptors agonist on food intake and its interaction with glutamatergic in 3-h food-deprived (FD3) neonatal broilers.

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 02AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Efficacy outcome

    In neonatal chicks, co-injection of the antagonist SHU9119 with MTII significantly inhibited MTII-induced hypophagia.

    In plain wordsIn chicks, adding a blocker called SHU9119 reduced the appetite-lowering effect of MTII.

    Peptide
    Melanotan II
    Outcome
    IncreaseMTII-induced hypophagia with SHU9119 co-injection
    Study

    chickenn: not reported in source

    Neonatal meat-type chicks, 3-h food-deprived
    Comparator
    MTII alone
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Co-injection of SHU9119 + MTII significantly inhibited MTII- induced hypophagia in neonatal chicks (p < 0.05).
    1 context sentence
    Summary · context
    So, the aim of the current study was to determine the role of MC3/MC4 receptors agonist on food intake and its interaction with glutamatergic in 3-h food-deprived (FD3) neonatal broilers.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

  2. 03AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Efficacy outcome

    In neonatal chicks, co-injection of the NMDA receptor antagonist MK-801 with MTII significantly attenuated MTII-induced hypophagia.

    In plain wordsIn chicks, adding the NMDA blocker MK-801 reduced the appetite-lowering effect of MTII.

    Peptide
    Melanotan II
    Outcome
    IncreaseMTII-induced hypophagia with MK-801 co-injection
    Study

    chickenn: not reported in source

    Neonatal meat-type chicks, 3-h food-deprived
    Comparator
    MTII alone
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    In addition, hypophagia- induced by MTII was significantly attenuated with co-injection of MTII + MK-801(p < 0.05).
    1 context sentence
    Summary · context
    So, the aim of the current study was to determine the role of MC3/MC4 receptors agonist on food intake and its interaction with glutamatergic in 3-h food-deprived (FD3) neonatal broilers.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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