Melanotan I (afamelanotide) studies: 218 papers with results
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- Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice.
Fu S · Oxidative medicine and cellular longevity · 2020
Animal study (in vivo) · mouse · 11 results
- Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism.
Ottani A · European journal of pharmacology · 2010
Animal study (in vivo) · rat · 6 results
- Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils.
Giuliani D · European journal of pharmacology · 2006
Animal study (in vivo) · mongolian gerbil · 5 results
- The role of melanocortin-3 and -4 receptor in regulating appetite, energy homeostasis and neuroendocrine function in the pig.
Barb CR · The Journal of endocrinology · 2004
Animal study (in vivo) · pig · 6 results
- alpha-Melanocyte-stimulating hormone protects the allograft in experimental heart transplantation.
Gatti S · Transplantation · 2002
Animal study (in vivo) · rat · 5 results
- Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268.
Giuliani D · Brain, behavior, and immunity · 2009
Animal study (in vivo) · gerbil · 6 results
- Protective action of NDP-MSH in experimental subarachnoid hemorrhage.
Gatti S · Experimental neurology · 2012
Animal study (in vivo) · rat · 5 results
- Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression.
Morgan C · Behavior genetics · 2006
Animal study (in vivo) · mouse · 9 results
- Alpha-melanocyte stimulating hormone ameliorates disease activity in an induced murine lupus-like model.
Botte DA · Clinical and experimental immunology · 2014
Animal study (in vivo) · mouse · 9 results
- Pancreatic neuronal melanocortin-4 receptor modulates serum insulin levels independent of leptin receptor.
Mansour M · Endocrine · 2010
Animal study (in vivo) · rat · 8 results
- Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury.
Colombo G · Shock (Augusta, Ga.) · 2007
Animal study (in vivo) · rat · 5 results
- Nr4a1 siRNA expression attenuates α-MSH regulated gene expression in 3T3-L1 adipocytes.
Wang SC · Molecular endocrinology (Baltimore, Md.) · 2011
Animal study (in vivo) · mouse · 18 results
- γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R.
Joseph CG · Peptides · 2010
Animal study (in vivo) · mouse · 2 results
- Gene expression profiling reveals multiple protective influences of the peptide alpha-melanocyte-stimulating hormone in experimental heart transplantation.
Colombo G · Journal of immunology (Baltimore, Md. : 1950) · 2005
Animal study (in vivo) · rat · 15 results
- Different cardiovascular profiles of three melanocortins in conscious rats; evidence for antagonism between gamma 2-MSH and ACTH-(1-24).
Van Bergen P · British journal of pharmacology · 1997
Animal study (in vivo) · rat · 2 results
- Toxicologic studies of a superpotent alpha-melanotropin, [Nle4, D-Phe7]alpha-MSH.
Dorr RT · Investigational new drugs · 1988
Animal study (in vivo) · mouse · 8 results
- Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling.
Qiao Y · Clinical science (London, England : 1979) · 2020
Animal study (in vivo) · mouse · 13 results
- The peptide NDP-MSH induces phenotype changes in the heart that resemble ischemic preconditioning.
Catania A · Peptides · 2010
Animal study (in vivo) · rat · 8 results
- Corticotropin-releasing factor (CRF) is involved in the acute anorexic effect of alpha-melanocyte-stimulating hormone: a study using CRF-deficient mice.
Kawashima S · Peptides · 2008
Animal study (in vivo) · mouse · 6 results
- Modulatory effects of NDP-MSH in the regenerating liver after partial hepatectomy in rats.
Lonati C · Peptides · 2013
Animal study (in vivo) · rat · 6 results
- Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson's Disease.
Srivastava P · Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
Animal study (in vivo) · mouse · 9 results
- Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy.
Guan X · Kidney international · 2023
Animal study (in vivo) · mouse · 2 results
- NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis.
Figueiredo J · Naunyn-Schmiedeberg's archives of pharmacology · 2013
Animal study (in vivo) · 13 results
- Treatment with alpha-melanocyte stimulating hormone preserves calcium regulatory proteins in rat heart allografts.
Colombo G · Brain, behavior, and immunity · 2008
Animal study (in vivo) · rat · 4 results
- Structure-activity analysis for the effects of gamma-MSH/ACTH-like peptides on cerebral hemodynamics in rats.
Van Bergen P · European journal of pharmacology · 1996
Animal study (in vivo) · rat · 3 results
- Melanocortins and opioids modulate early postnatal growth in rats.
Mauri A · Regulatory peptides · 1995
Animal study (in vivo) · rat · 4 results
- Nicotine-induced Brain Stimulation Reward is Modulated by Melanocortin-4 Receptors in Ovariectomized Rats.
Upadhya MA · Neuroscience · 2020
Animal study (in vivo) · rat · 2 results
- Pharmacologic response of a controlled-release PLGA formulation for the alpha-melanocyte stimulating hormone analog, Melanotan-I.
Bhardwaj R · Pharmaceutical research · 2000
Animal study (in vivo) · guinea pig · 3 results
- Activation of the melanocortin-1 receptor attenuates neuronal apoptosis after traumatic brain injury by upregulating Merlin expression.
Lu J · Brain research bulletin · 2024
Animal study (in vivo) · rat · 5 results
- The role of calcium in MSH stimulated melanosome dispersion.
Lucas AM · Peptides · 1987
Animal study (in vivo) · anolis carolinensis (lizard) · 1 result
- NDP-MSH rescues LPS-induced neuroinflammation, synaptic deficits, and depressive-like behaviors in mice: involvement of MC1R-cAMP/PKA signaling.
Qu S · Frontiers in pharmacology · 2026
Animal study (in vivo) · mouse · 11 results
- The Synthetic Melanocortin Agonist NDP-MSH Ameliorates THSD7A-Associated Membranous Nephropathy in an Active Immunization Mouse Model.
Zhang M · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
Animal study (in vivo) · mouse · 10 results
- A gel-forming α-MSH analog promotes lasting melanogenesis.
Chang CL · European journal of pharmacology · 2023
Animal study (in vivo) · frog · 5 results
- Melanotropin receptors demonstrated in situ in human melanoma.
Tatro JB · The Journal of clinical investigation · 1990
Ex vivo tissue · 4 results
- Melanotropin receptors in the brain are differentially distributed and recognize both corticotropin and alpha-melanocyte stimulating hormone.
Tatro JB · Brain research · 1990
Ex vivo tissue · rat · 3 results
- Hypothalamic interactions between neuropeptide Y, agouti-related protein, cocaine- and amphetamine-regulated transcript and alpha-melanocyte-stimulating hormone in vitro in male rats.
Dhillo WS · Journal of neuroendocrinology · 2002
Ex vivo tissue · rat · 2 results
- Interaction of an alpha-melanocyte-stimulating hormone-diphtheria toxin fusion protein with melanotropin receptors in human melanoma metastases.
Tatro JB · Cancer research · 1992
Ex vivo tissue · mouse · 4 results
- Heterogeneity of brain melanocortin receptors suggested by differential ligand binding in situ.
Tatro JB · Brain research · 1994
Ex vivo tissue · rat · 4 results
- Melanotropin receptors of murine melanoma characterized in cultured cells and demonstrated in experimental tumors in situ.
Tatro JB · Cancer research · 1990
Ex vivo tissue · mouse · 4 results
- Effects of melanocortin-4 receptor agonists and antagonists on expression of genes related to reproduction in spotted scat, Scatophagus argus.
Jiang DN · Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017
Ex vivo tissue · spotted scat (scatophagus argus) · 3 results
- Characterization of functional melanotropin receptors in lacrimal glands of the rat.
Entwistle ML · Peptides · 1990
Ex vivo tissue · rat · 5 results
- Weak functional coupling of the melanocortin-1 receptor expressed in human adipocytes.
Hoch M · Journal of receptor and signal transduction research · 2008
Ex vivo tissue · 7 results
- Opioid peptide inhibition of endogenous norepinephrine release from the A2 noradrenergic cell group in vitro.
Carr JA · Neuropeptides · 1995
Ex vivo tissue · rat · 2 results
- L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion.
Kuhre RE · Frontiers in endocrinology · 2021
Ex vivo tissue · mouse and rat · 3 results
- Molecular cloning and characterization of the rat fifth melanocortin receptor.
Griffon N · Biochemical and biophysical research communications · 1994
In vitro (cells) · rat receptor · 2 results
- Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues.
Labbé O · Biochemistry · 1994
In vitro (cells) · mouse receptor in hamster cells · 3 results
- Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line.
Boston BA · Endocrinology · 1996
In vitro (cells) · mouse · 2 results
- Major pharmacological distinction of the ACTH receptor from other melanocortin receptors.
Schiöth HB · Life sciences · 1996
In vitro (cells) · mouse · 2 results
- Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene.
Desarnaud F · The Biochemical journal · 1994
In vitro (cells) · mouse receptor · 2 results
- Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase.
Chai B · Peptides · 2006
In vitro (cells) · 7 results