Modulatory effects of NDP-MSH in the regenerating liver after partial hepatectomy in rats.

Lonati C, Carlin A, Leonardi P, Valenza F, Bosari S, Catania A, Gatti S

Peptides1 Dec 2013Cited by 13 (Europe PMC)

PMID24446557DOI10.1016/j.peptides.2013.10.014PepBankPUB-24446557

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats after partial hepatectomy, NDP-MSH modulated the expression of a substantial proportion of the altered transcripts, including several chemokines and their receptors.
In plain wordsIn rats after part of the liver was removed, NDP-MSH changed the activity of many genes, including some for chemokines.
Peptide
Melanotan I (afamelanotide)
Outcome
MixedExpression of partial-hepatectomy-altered transcripts including chemokines and receptors
Study
ratn: not reported in source
70% partial hepatectomy
Comparator
Saline
Outcome group
Organ injury · Liver
Studied dose
Dose not stated · intravenous · single injectionAs given in this study (rat).
Source sentences
Summary
Real-time PCR analysis revealed that NDP-MSH modulated the expression of a substantial proportion of these transcripts including several chemokines and their receptors.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats under isoflurane anesthesia were subjected to standard 70% PH or sham surgery.
Summary · context
Animals received a single i.v. injection of Nle4, DPhe7-α-melanocyte stimulating hormone (NDP-MSH) or saline 30 min before surgery.
Report a problemFND-2444655701
02AnimalAnimal study (in vivo)Mechanism
In rats after partial hepatectomy, NDP-MSH significantly enhanced the interleukin-6/STAT/SOCS signaling pathway.
In plain wordsIn rats after part of the liver was removed, NDP-MSH strengthened the IL-6 signaling pathway.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseIL-6/STAT/SOCS signaling pathway
Study
ratn: not reported in source
70% partial hepatectomy
Comparator
Saline
Outcome group
Organ injury · Liver
Studied dose
Dose not stated · intravenous · single injectionAs given in this study (rat).
Source sentences
Summary
The critical signaling pathway interleukin-6 (IL-6)/signal transducer and activator of transcription (STAT)/suppressor of cytokine signaling (SOCS) was significantly enhanced by NDP-MSH.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats under isoflurane anesthesia were subjected to standard 70% PH or sham surgery.
Summary · context
Animals received a single i.v. injection of Nle4, DPhe7-α-melanocyte stimulating hormone (NDP-MSH) or saline 30 min before surgery.
Report a problemFND-2444655702
03AnimalAnimal study (in vivo)Mechanism
In rats after partial hepatectomy, NDP-MSH considerably reduced the decline of IκBα protein caused by the surgery.
In plain wordsIn rats after part of the liver was removed, NDP-MSH reduced the drop in IκBα protein caused by the surgery.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseIκBα protein decline after partial hepatectomy
Study
ratn: not reported in source
70% partial hepatectomy
Comparator
Saline
Outcome group
Organ injury · Liver
Studied dose
Dose not stated · intravenous · single injectionAs given in this study (rat).
Source sentences
Summary
Further, peptide treatment considerably reduced the decline of IκBα protein caused by PH.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats under isoflurane anesthesia were subjected to standard 70% PH or sham surgery.
Summary · context
Animals received a single i.v. injection of Nle4, DPhe7-α-melanocyte stimulating hormone (NDP-MSH) or saline 30 min before surgery.
Report a problemFND-2444655703
04AnimalAnimal study (in vivo)Efficacy outcome
In rats after partial hepatectomy, NDP-MSH did not substantially affect final organ regeneration.
In plain wordsIn rats after part of the liver was removed, NDP-MSH did not substantially change how well the liver regrew.
Peptide
Melanotan I (afamelanotide)
Outcome
No significant changeFinal organ regeneration
Study
ratn: not reported in source
70% partial hepatectomy
Comparator
Saline
Outcome group
Organ injury · Liver
Studied dose
Dose not stated · intravenous · single injectionAs given in this study (rat).
Source sentences
Summary
Although the final organ regeneration was not substantially affected
2 context sentences(design, population, supporting numbers)
Summary · context
Rats under isoflurane anesthesia were subjected to standard 70% PH or sham surgery.
Summary · context
Animals received a single i.v. injection of Nle4, DPhe7-α-melanocyte stimulating hormone (NDP-MSH) or saline 30 min before surgery.
Report a problemFND-2444655704
05AnimalAnimal study (in vivo)Mechanism
In rats after partial hepatectomy, NDP-MSH modulated the expression of cell cycle mediators.
In plain wordsIn rats after part of the liver was removed, NDP-MSH changed the activity of genes that control cell division.
Peptide
Melanotan I (afamelanotide)
Outcome
MixedExpression of cell cycle mediators
Study
ratn: not reported in source
70% partial hepatectomy
Comparator
Saline
Outcome group
Organ injury · Liver
Studied dose
Dose not stated · intravenous · single injectionAs given in this study (rat).
Source sentences
Summary
NDP-MSH modulated expression of cell cycle mediators and exerted subtle influences on hepatocyte replication.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats under isoflurane anesthesia were subjected to standard 70% PH or sham surgery.
Summary · context
Animals received a single i.v. injection of Nle4, DPhe7-α-melanocyte stimulating hormone (NDP-MSH) or saline 30 min before surgery.
Report a problemFND-2444655705
06AnimalAnimal study (in vivo)Efficacy outcome
In rats after partial hepatectomy, NDP-MSH exerted subtle influences on hepatocyte replication.
In plain wordsIn rats after part of the liver was removed, NDP-MSH had small effects on liver cell replication.
Peptide
Melanotan I (afamelanotide)
Outcome
MixedHepatocyte replication
Study
ratn: not reported in source
70% partial hepatectomy
Comparator
Saline
Outcome group
Organ injury · Liver
Studied dose
Dose not stated · intravenous · single injectionAs given in this study (rat).
Source sentences
Summary
exerted subtle influences on hepatocyte replication.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats under isoflurane anesthesia were subjected to standard 70% PH or sham surgery.
Summary · context
Animals received a single i.v. injection of Nle4, DPhe7-α-melanocyte stimulating hormone (NDP-MSH) or saline 30 min before surgery.
Report a problemFND-2444655706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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