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Study · Ex vivo tissue · rat · 2002

2 results

Hypothalamic interactions between neuropeptide Y, agouti-related protein, cocaine- and amphetamine-regulated transcript and alpha-melanocyte-stimulating hormone in vitro in male rats.

Dhillo WS, Small CJ, Stanley SA, Jethwa PH, Seal LJ, Murphy KG, Ghatei MA, Bloom SR

Journal of neuroendocrinology1 Sept 2002Cited by 49 (Europe PMC)

PMID12213133 (opens in a new tab)DOI10.1046/j.1365-2826.2002.00832.x (opens in a new tab)PepBankPUB-12213133
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat hypothalamic explants, NDP-MSH (10 nm) significantly increased the release of NPY-immunoreactivity.

    In plain wordsIn rat brain tissue samples, NDP-MSH increased the release of neuropeptide Y.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseNPY-IR release from hypothalamic explants
    Study

    ratn: not reported in source

    hypothalamic explants
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    10 nmAs given in this study (rat).

    Source sentences

    Summary
    NDP-MSH (10 nm) administered to hypothalamic explants significantly increased the release of NPY-IR.
    1 context sentence
    Summary · context
    We investigated possible interactions between these neuropeptides in vitro using a rat hypothalamic explant system.
  2. 02LabEx vivo tissueMechanism

    In rat hypothalamic explants, NDP-MSH (10 and 100 nm) significantly increased the release of Agrp(83-132)-immunoreactivity.

    In plain wordsIn rat brain tissue samples, NDP-MSH increased the release of agouti-related protein.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseAgrp(83-132)-IR release from hypothalamic explants
    Study

    ratn: not reported in source

    hypothalamic explants
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    10 and 100 nmAs given in this study (rat).

    Source sentences

    Summary
    NDP-MSH (10 and 100 nm) significantly increased the release of Agrp(83-132)-IR from hypothalamic explants.
    1 context sentence
    Summary · context
    We investigated possible interactions between these neuropeptides in vitro using a rat hypothalamic explant system.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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