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Study · Ex vivo tissue · rat · 1995

2 results

Opioid peptide inhibition of endogenous norepinephrine release from the A2 noradrenergic cell group in vitro.

Carr JA, Gregg KJ

Neuropeptides1 Apr 1995Cited by 10 (Europe PMC)

PMID7596487 (opens in a new tab)DOI10.1016/0143-4179(95)90025-x (opens in a new tab)PepBankPUB-07596487
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In rat medulla slices, NDP-MSH had no effect on potassium-induced norepinephrine release.

    In plain wordsIn lab tests on rat brain slices, NDP-MSH did not change norepinephrine release.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeK+-induced norepinephrine release
    Study

    ratn: not reported in source

    slices of caudal dorsomedial medulla
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with the potent melanotropin agonist [Nle4,D-Phe7] alpha-MSH(NDP-MSH) had no effect on K(+)-induced NE release.
    1 context sentence
    Summary · context
    Norepinephrine release from slices of caudal dorsomedial medulla (CDMM) was evoked by high potassium concentrations (20 and 60 mM) in a Ca(2+)-dependent and dose-related manner.
  2. 02LabEx vivo tissueEfficacy outcome

    In rat medulla slices, none of the peptides tested, NDP-MSH included, influenced basal norepinephrine release.

    In plain wordsIn lab tests on rat brain slices, NDP-MSH did not change baseline norepinephrine release.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeBasal norepinephrine release
    Study

    ratn: not reported in source

    slices of caudal dorsomedial medulla
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    None of the peptides tested influenced basal NE release.
    2 context sentences
    Summary · context
    Treatment with the potent melanotropin agonist [Nle4,D-Phe7] alpha-MSH(NDP-MSH)
    Summary · context
    Norepinephrine release from slices of caudal dorsomedial medulla (CDMM) was evoked by high potassium concentrations (20 and 60 mM) in a Ca(2+)-dependent and dose-related manner.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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