Skip to content

Study · Animal study (in vivo) · rat · 2010

8 results

The peptide NDP-MSH induces phenotype changes in the heart that resemble ischemic preconditioning.

Catania A, Lonati C, Sordi A, Leonardi P, Carlin A, Gatti S

Peptides30 Sept 2009Cited by 16 (Europe PMC)

PMID19799952 (opens in a new tab)DOI10.1016/j.peptides.2009.09.030 (opens in a new tab)PepBankPUB-19799952
Publisher pagePubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, NDP-MSH produced an early and marked increase in interleukin 6 mRNA in the heart.

    In plain wordsIn rats, NDP-MSH raised the activity of the IL-6 gene in the heart early after injection.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseCardiac IL-6 mRNA
    Study

    ratn: not reported in source

    Rat heart tissue after a single injection
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    750microg/kg · intravenous · single injection, sacrificed at 0.5, 1, 3 or 5 hAs given in this study (rat).

    Source sentences

    Summary
    Treatment with NDP-MSH was associated with early and marked increase in interleukin 6 (IL-6) mRNA.
    1 context sentence
    Summary · context
    Rats received single i.v. injections of 750microg/kg of the alpha-MSH analogue Nle(4),DPhe(7)-alpha-MSH (NDP-MSH) or saline and were sacrificed at 0.5, 1, 3, or 5h.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, the early IL-6 rise after NDP-MSH was followed by STAT3 phosphorylation in the heart.

    In plain wordsIn rats, NDP-MSH was followed by activation of the STAT3 signal in the heart.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseCardiac STAT3 phosphorylation
    Study

    ratn: not reported in source

    Rat heart tissue after a single injection
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    750microg/kg · intravenous · single injection, sacrificed at 0.5, 1, 3 or 5 hAs given in this study (rat).

    Source sentences

    Summary
    This was followed by signal transducer and activator of transcription 3 (STAT3) phosphorylation and induction of suppressor of cytokine signaling 3 (SOCS3).
    1 context sentence
    Summary · context
    Rats received single i.v. injections of 750microg/kg of the alpha-MSH analogue Nle(4),DPhe(7)-alpha-MSH (NDP-MSH) or saline and were sacrificed at 0.5, 1, 3, or 5h.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, the early IL-6 rise after NDP-MSH was followed by induction of SOCS3 in the heart.

    In plain wordsIn rats, NDP-MSH was followed by a rise in the SOCS3 protein in the heart.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseCardiac SOCS3 induction
    Study

    ratn: not reported in source

    Rat heart tissue after a single injection
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    750microg/kg · intravenous · single injection, sacrificed at 0.5, 1, 3 or 5 hAs given in this study (rat).

    Source sentences

    Summary
    This was followed by signal transducer and activator of transcription 3 (STAT3) phosphorylation and induction of suppressor of cytokine signaling 3 (SOCS3).
    1 context sentence
    Summary · context
    Rats received single i.v. injections of 750microg/kg of the alpha-MSH analogue Nle(4),DPhe(7)-alpha-MSH (NDP-MSH) or saline and were sacrificed at 0.5, 1, 3, or 5h.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, NDP-MSH did not change expression of other cytokines of the IL-6 family in the heart.

    In plain wordsIn rats, NDP-MSH did not change other IL-6 family messengers in the heart.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeExpression of other IL-6 family cytokines
    Study

    ratn: not reported in source

    Rat heart tissue after a single injection
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    750microg/kg · intravenous · single injection, sacrificed at 0.5, 1, 3 or 5 hAs given in this study (rat).

    Source sentences

    Summary
    There were no changes in expression of other cytokines of the IL-6 family.
    1 context sentence
    Summary · context
    Rats received single i.v. injections of 750microg/kg of the alpha-MSH analogue Nle(4),DPhe(7)-alpha-MSH (NDP-MSH) or saline and were sacrificed at 0.5, 1, 3, or 5h.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, NDP-MSH left IL-10 expression in the heart unaltered.

    In plain wordsIn rats, NDP-MSH did not change IL-10 in the heart.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeCardiac IL-10 expression
    Study

    ratn: not reported in source

    Rat heart tissue after a single injection
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    750microg/kg · intravenous · single injection, sacrificed at 0.5, 1, 3 or 5 hAs given in this study (rat).

    Source sentences

    Summary
    Expression of IL-10, IL-1beta, and TNF-alpha was likewise unaltered.
    1 context sentence
    Summary · context
    Rats received single i.v. injections of 750microg/kg of the alpha-MSH analogue Nle(4),DPhe(7)-alpha-MSH (NDP-MSH) or saline and were sacrificed at 0.5, 1, 3, or 5h.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, NDP-MSH left IL-1beta expression in the heart unaltered.

    In plain wordsIn rats, NDP-MSH did not change IL-1beta in the heart.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeCardiac IL-1beta expression
    Study

    ratn: not reported in source

    Rat heart tissue after a single injection
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    750microg/kg · intravenous · single injection, sacrificed at 0.5, 1, 3 or 5 hAs given in this study (rat).

    Source sentences

    Summary
    Expression of IL-10, IL-1beta, and TNF-alpha was likewise unaltered.
    1 context sentence
    Summary · context
    Rats received single i.v. injections of 750microg/kg of the alpha-MSH analogue Nle(4),DPhe(7)-alpha-MSH (NDP-MSH) or saline and were sacrificed at 0.5, 1, 3, or 5h.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, NDP-MSH left TNF-alpha expression in the heart unaltered.

    In plain wordsIn rats, NDP-MSH did not change TNF-alpha in the heart.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeCardiac TNF-alpha expression
    Study

    ratn: not reported in source

    Rat heart tissue after a single injection
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    750microg/kg · intravenous · single injection, sacrificed at 0.5, 1, 3 or 5 hAs given in this study (rat).

    Source sentences

    Summary
    Expression of IL-10, IL-1beta, and TNF-alpha was likewise unaltered.
    1 context sentence
    Summary · context
    Rats received single i.v. injections of 750microg/kg of the alpha-MSH analogue Nle(4),DPhe(7)-alpha-MSH (NDP-MSH) or saline and were sacrificed at 0.5, 1, 3, or 5h.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats, NDP-MSH increased expression of the orphan nuclear receptor Nur77 in the heart.

    In plain wordsIn rats, NDP-MSH raised the level of the Nur77 receptor in the heart.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseCardiac Nur77 expression
    Study

    ratn: not reported in source

    Rat heart tissue after a single injection
    Comparator
    Saline
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    750microg/kg · intravenous · single injection, sacrificed at 0.5, 1, 3 or 5 hAs given in this study (rat).

    Source sentences

    Summary
    In hearts of rats treated with NDP-MSH there was increased expression of the orphan nuclear receptor Nur77.
    1 context sentence
    Summary · context
    Rats received single i.v. injections of 750microg/kg of the alpha-MSH analogue Nle(4),DPhe(7)-alpha-MSH (NDP-MSH) or saline and were sacrificed at 0.5, 1, 3, or 5h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.