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Study · Animal study (in vivo) · rat · 1995

4 results

Melanocortins and opioids modulate early postnatal growth in rats.

Mauri A, Melis MR, Deiana P, Loviselli A, Volpe A, Argiolas A

Regulatory peptides1 Sept 1995Cited by 8 (Europe PMC)

PMID12506415 (opens in a new tab)DOI10.1016/0167-0115(95)00074-l (opens in a new tab)PepBankPUB-12506415
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats, Nle4-D-Phe7 alpha-MSH at 3 micrograms/g/day, like alpha-MSH, increased body weight; weight rises of 4.2 and 3% were reported for the two peptides.

    In plain wordsIn newborn rats, NDP-MSH and alpha-MSH both raised body weight, by 4.2 and 3% across the two peptides.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseNeonatal body weight gain
    Study

    ratn: not reported in source

    neonatal rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    3 micrograms/g/day · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Likewise, a weight rise of 4.2 and 3% was obtained with 3 micrograms/g/day of both alpha-MSH and Nle4-D-Phe7 alpha-MSH.
    2 context sentences
    Summary · context
    after 2 weeks of treatment.
    Summary · context
    This study was undertaken to investigate the effects of melanocortins and opioids on rat early postnatal body and organ growth.

Studies that did not test the peptide alone3

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 02AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Efficacy outcome

    In neonatal rats, all melanocortins tested, as a group, had a positive action on muscular trophism.

    In plain wordsIn newborn rats, the melanocortin peptides tested as a group had a positive effect on muscle.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMuscular trophism
    Study

    ratn: not reported in source

    neonatal rats
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    All melanocortins exerted a positive action on muscular and brain trophism
    1 context sentence
    Summary · context
    This study was undertaken to investigate the effects of melanocortins and opioids on rat early postnatal body and organ growth.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  2. 03AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Efficacy outcome

    In neonatal rats, all melanocortins tested, as a group, had a positive action on brain trophism.

    In plain wordsIn newborn rats, the melanocortin peptides tested as a group had a positive effect on brain.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseBrain trophism
    Study

    ratn: not reported in source

    neonatal rats
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    All melanocortins exerted a positive action on muscular and brain trophism
    1 context sentence
    Summary · context
    This study was undertaken to investigate the effects of melanocortins and opioids on rat early postnatal body and organ growth.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

  3. 04AnimalNot a test of Melanotan I (afamelanotide) aloneAnimal study (in vivo)Efficacy outcome

    In neonatal rats, none of the tested melanocortins and opioids modified corticosterone concentrations.

    In plain wordsIn newborn rats, none of the tested melanocortins or opioids changed corticosterone levels.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeCorticosterone concentration
    Study

    ratn: not reported in source

    neonatal rats
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    All tested melanocortins and opioids failed to modify the concentrations of corticosterone.
    1 context sentence
    Summary · context
    This study was undertaken to investigate the effects of melanocortins and opioids on rat early postnatal body and organ growth.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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