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Study · Ex vivo tissue · spotted scat (scatophagus argus) · 2017

3 results

Effects of melanocortin-4 receptor agonists and antagonists on expression of genes related to reproduction in spotted scat, Scatophagus argus.

Jiang DN, Li JT, Tao YX, Chen HP, Deng SP, Zhu CH, Li GL

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology14 Feb 2017Cited by 24 (Europe PMC)

PMID28197776 (opens in a new tab)DOI10.1007/s00360-017-1062-0 (opens in a new tab)PepBankPUB-28197776
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In incubated spotted scat hypothalamus, NDP-MSH significantly increased gnrh expression after 3 h.

    In plain wordsIn fish brain tissue kept in the lab, NDP-MSH raised expression of the reproductive hormone gene gnrh.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Increasegnrh expression in incubated hypothalamus
    Study

    spotted scat (Scatophagus argus)n: not reported in source

    incubated hypothalamus
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10^-6 M · 3 hAs given in this study (spotted scat (Scatophagus argus)).

    Source sentences

    Summary
    Using in vitro incubated hypothalamus, the Mc4r nonselective agonist NDP-MSH ([Nle4, D-Phe7]-α-melanocyte stimulating hormone; 10-6 M) and selective agonist THIQ
    1 context sentence
    Summary · context
    Here, we report on gene expression changes by real-time PCR following treatment with Mc4r agonists and antagonists in the spotted scat (Scatophagus argus).
  2. 02LabEx vivo tissueMechanism

    In incubated spotted scat pituitary tissue, NDP-MSH significantly increased fshb expression after 3 h.

    In plain wordsIn fish pituitary tissue kept in the lab, NDP-MSH raised expression of the fshb gene.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Increasefshb expression in incubated pituitary
    Study

    spotted scat (Scatophagus argus)n: not reported in source

    incubated pituitary tissue
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10^-6 M · 3 hAs given in this study (spotted scat (Scatophagus argus)).

    Source sentences

    Summary
    In incubated pituitary tissue, NDP-MSH and THIQ significantly increased the expression of fshb (Follicle-stimulating hormone beta subunit) and lhb (Luteinizing hormone beta subunit), while SHU9119 and Ipsen 5i significantly decreased fshb and lhb expression after 3 h of incubation.
    1 context sentence
    Summary · context
    Here, we report on gene expression changes by real-time PCR following treatment with Mc4r agonists and antagonists in the spotted scat (Scatophagus argus).
  3. 03LabEx vivo tissueMechanism

    In incubated spotted scat pituitary tissue, NDP-MSH significantly increased lhb expression after 3 h.

    In plain wordsIn fish pituitary tissue kept in the lab, NDP-MSH raised expression of the lhb gene.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Increaselhb expression in incubated pituitary
    Study

    spotted scat (Scatophagus argus)n: not reported in source

    incubated pituitary tissue
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10^-6 M · 3 hAs given in this study (spotted scat (Scatophagus argus)).

    Source sentences

    Summary
    In incubated pituitary tissue, NDP-MSH and THIQ significantly increased the expression of fshb (Follicle-stimulating hormone beta subunit) and lhb (Luteinizing hormone beta subunit), while SHU9119 and Ipsen 5i significantly decreased fshb and lhb expression after 3 h of incubation.
    1 context sentence
    Summary · context
    Here, we report on gene expression changes by real-time PCR following treatment with Mc4r agonists and antagonists in the spotted scat (Scatophagus argus).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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