In lizard melanophores, the alpha-MSH analogue Nle4-D-Phe7-alpha-MSH showed kinetically that calcium is involved in MSH receptor binding and in signal transduction across the membrane.
In plain wordsIn lizard pigment cells, the melanotan I analogue showed that calcium takes part in how the cells respond to the hormone.
- Peptide
- Melanotan I (afamelanotide)
- Outcome
- Not applicableCalcium involvement in melanophore response to the alpha-MSH analogue
- Study
Anolis carolinensis (lizard)n: not reported in source
Lizard melanophores, melanosome dispersion assay- Outcome group
- Receptor activity and mechanism · Skin and wound
- Studied dose
- Dose not stated
Source sentences
An avidly binding analogue of alpha-MSH, Nle4-D-Phe7-alpha-MSH, was used to demonstrate kinetically the involvement of calcium in the melanophore response both for MSH receptor binding and the subsequent transduction of the MSH signal across the melanophore membrane.
1 context sentence(design, population, supporting numbers)
We have examined the role of the calcium ion in the response of the melanophores of the lizard, Anolis carolinensis to alpha-melanocyte stimulating hormone (alpha-MSH) by a rate method which allows kinetic analysis of melanosome dispersion.