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Study · Animal study (in vivo) · mouse · 2006

9 results

Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression.

Morgan C, Cone RD

Behavior genetics12 Jan 2006Cited by 26 (Europe PMC)

PMID16408249 (opens in a new tab)DOI10.1007/s10519-005-9024-9 (opens in a new tab)PepBankPUB-16408249
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type male mice, repeated NDP-MSH injection decreased attack latency in initial attackers.

    In plain wordsIn mice, repeated NDP-MSH injections shortened the time to the first attack.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseAttack latency in wild-type pairs
    Study

    mousen: not reported in source

    Male mice, pheromone-induced aggression
    Comparator
    Vehicle
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In wild-type (MC5R(+/+)) pairs, repeated NDP-MSH injection decreased attack latency and increased aggression in initial attackers.
    1 context sentence
    Summary · context
    We investigated whether MC5R deficiency in male mice alters stimulatory melanocortin influences on preputial growth and pheromone-induced aggression.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type male mice, repeated NDP-MSH injection increased aggression in initial attackers.

    In plain wordsIn mice, repeated NDP-MSH injections increased aggression.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseAggression in wild-type pairs
    Study

    mousen: not reported in source

    Male mice, pheromone-induced aggression
    Comparator
    Vehicle
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In wild-type (MC5R(+/+)) pairs, repeated NDP-MSH injection decreased attack latency and increased aggression in initial attackers.
    1 context sentence
    Summary · context
    We investigated whether MC5R deficiency in male mice alters stimulatory melanocortin influences on preputial growth and pheromone-induced aggression.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In MC5R-deficient male mice, NDP-MSH treatment did not alter attack latency.

    In plain wordsIn mice without the MC5 receptor, NDP-MSH did not change the time to the first attack.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeAttack latency in MC5R-deficient pairs
    Study

    mousen: not reported in source

    Male mice, pheromone-induced aggression
    Comparator
    Vehicle
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similar NDP-MSH treatment in MC5R-deficient (MC5R(-/-)) pairs failed to alter attack latency or aggression frequency, but aggression increased in vehicle-injected opponents.
    1 context sentence
    Summary · context
    We investigated whether MC5R deficiency in male mice alters stimulatory melanocortin influences on preputial growth and pheromone-induced aggression.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In MC5R-deficient male mice, NDP-MSH treatment did not alter aggression frequency.

    In plain wordsIn mice without the MC5 receptor, NDP-MSH did not change how often they were aggressive.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeAggression frequency in MC5R-deficient pairs
    Study

    mousen: not reported in source

    Male mice, pheromone-induced aggression
    Comparator
    Vehicle
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similar NDP-MSH treatment in MC5R-deficient (MC5R(-/-)) pairs failed to alter attack latency or aggression frequency, but aggression increased in vehicle-injected opponents.
    1 context sentence
    Summary · context
    We investigated whether MC5R deficiency in male mice alters stimulatory melanocortin influences on preputial growth and pheromone-induced aggression.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In male mice, NDP-MSH treatment promoted preputial gland hypertrophy.

    In plain wordsIn mice, NDP-MSH treatment enlarged the preputial gland.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreasePreputial hypertrophy
    Study

    mousen: not reported in source

    Male mice, pheromone-induced aggression
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH treatment promoted preputial hypertrophy
    1 context sentence
    Summary · context
    We investigated whether MC5R deficiency in male mice alters stimulatory melanocortin influences on preputial growth and pheromone-induced aggression.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type male mice paired against non-aggressive stimulus opponents, NDP-MSH decreased attack latency.

    In plain wordsIn mice paired with non-aggressive partners, NDP-MSH shortened the time to attack.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseAttack latency against non-aggressive stimulus opponents
    Study

    mousen: not reported in source

    Male mice, pheromone-induced aggression
    Comparator
    Vehicle
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH treatment promoted preputial hypertrophy, and in MC5R(+/+) mice paired against non-aggressive stimulus opponents it decreased attack latency and increased aggression.
    1 context sentence
    Summary · context
    We investigated whether MC5R deficiency in male mice alters stimulatory melanocortin influences on preputial growth and pheromone-induced aggression.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type male mice paired against non-aggressive stimulus opponents, NDP-MSH increased aggression.

    In plain wordsIn mice paired with non-aggressive partners, NDP-MSH increased aggression.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseAggression against non-aggressive stimulus opponents
    Study

    mousen: not reported in source

    Male mice, pheromone-induced aggression
    Comparator
    Vehicle
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH treatment promoted preputial hypertrophy, and in MC5R(+/+) mice paired against non-aggressive stimulus opponents it decreased attack latency and increased aggression.
    1 context sentence
    Summary · context
    We investigated whether MC5R deficiency in male mice alters stimulatory melanocortin influences on preputial growth and pheromone-induced aggression.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    MC5R-deficient mice were insensitive to the behavioral and physiological effects of NDP-MSH.

    In plain wordsIn mice without the MC5 receptor, NDP-MSH had no behavioral or body effects.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeBehavioral and physiological effects in MC5R-deficient mice
    Study

    mousen: not reported in source

    Male mice, pheromone-induced aggression
    Comparator
    Vehicle
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MC5R(-/-) mice were insensitive to behavioral and physiological effects of NDP-MSH
    1 context sentence
    Summary · context
    We investigated whether MC5R deficiency in male mice alters stimulatory melanocortin influences on preputial growth and pheromone-induced aggression.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    Preputialectomized mice were insensitive to the behavioral effects of NDP-MSH.

    In plain wordsIn mice with the preputial glands removed, NDP-MSH had no behavioral effects.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeBehavioral effects in preputialectomized mice
    Study

    mousen: not reported in source

    Male mice, pheromone-induced aggression
    Comparator
    Vehicle
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and preputialectomized mice were insensitive to behavioral effects of NDP-MSH.
    1 context sentence
    Summary · context
    We investigated whether MC5R deficiency in male mice alters stimulatory melanocortin influences on preputial growth and pheromone-induced aggression.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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