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Study · Animal study (in vivo) · rat · 2020

2 results

Nicotine-induced Brain Stimulation Reward is Modulated by Melanocortin-4 Receptors in Ovariectomized Rats.

Upadhya MA, Upadhya HM, Borkar CD, Choudhary AG, Singh U, Chavan P, Sakharkar A, Singru P, Subhedar NK, Kokare DM

Neuroscience5 Feb 2020Cited by 6 (Europe PMC)

PMID32035118 (opens in a new tab)DOI10.1016/j.neuroscience.2020.01.035 (opens in a new tab)PepBankPUB-32035118
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats with a reward deficit, pre-administration of NDP-MSH restored rewarding activity in the intracranial self-stimulation protocol.

    In plain wordsIn rats with their ovaries removed, NDP-MSH given beforehand restored reward-seeking behavior that had fallen.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseRewarding activity in ovariectomized rats
    Study

    Ratn: not reported in source

    Ovariectomized rats trained in intracranial self-stimulation
    Comparator
    Ovariectomized rats without pre-administration
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, pre-administration with nicotine, alpha-melanocyte stimulating hormone (α-MSH) or NDP-MSH (MC4-R agonist) to OVX animals restored the rewarding activity in ICSS protocol
    1 context sentence
    Summary · context
    Trained OVX rats revealed a significant increase in threshold frequency and rightward shift in rate frequency curve, suggesting reward deficit behavior.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, prior treatment with a sub-effective dose of NDP-MSH potentiated the reward effect of nicotine.

    In plain wordsIn rats with their ovaries removed, a small NDP-MSH dose given before nicotine made the reward effect of nicotine stronger.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreasePotentiation of nicotine reward by sub-effective NDP-MSH
    Study

    Ratn: not reported in source

    Ovariectomized rats trained in intracranial self-stimulation
    Comparator
    Nicotine alone
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Prior treatment with sub-effective doses of α-MSH or NDP-MSH potentiated the reward effect of nicotine

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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