Skip to content

Study · Animal study (in vivo) · mouse · 2010

2 results

γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R.

Joseph CG, Yao H, Scott JW, Sorensen NB, Marnane RN, Mountjoy KG, Haskell-Luevano C

Peptides15 Sept 2010Cited by 18 (Europe PMC)

PMID20833220 (opens in a new tab)PMCIDPMC2967600 (opens in a new tab)DOI10.1016/j.peptides.2010.08.025 (opens in a new tab)PepBankPUB-20833220
Source linkPubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, intraperitoneal NDP-MSH reduced hypothalamic mMC3R mRNA levels compared with saline control.

    In plain wordsIn mice, NDP-MSH given by injection lowered the amount of MC3R messenger RNA in the hypothalamus compared with saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseHypothalamic MC3R mRNA level
    Study

    mousen: not reported in source

    Comparator
    Saline control
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The super potent non-selective NDP-MSH agonist was administered i.p. and resulted in significantly decreased levels of mMC3R and mMC5R hypothalamic mRNA versus saline control.
    1 context sentence
    Summary · context
    These results prompted us to examine the affects of a peripherally administered melanocortin agonist on hypothalamic gene expression levels of the MC3R, MC4R, and MC5R.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, intraperitoneal NDP-MSH reduced hypothalamic mMC5R mRNA levels compared with saline control.

    In plain wordsIn mice, NDP-MSH given by injection lowered the amount of MC5R messenger RNA in the hypothalamus compared with saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseHypothalamic MC5R mRNA level
    Study

    mousen: not reported in source

    Comparator
    Saline control
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The super potent non-selective NDP-MSH agonist was administered i.p. and resulted in significantly decreased levels of mMC3R and mMC5R hypothalamic mRNA versus saline control.
    1 context sentence
    Summary · context
    These results prompted us to examine the affects of a peripherally administered melanocortin agonist on hypothalamic gene expression levels of the MC3R, MC4R, and MC5R.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.