Gene expression profiling reveals multiple protective influences of the peptide alpha-melanocyte-stimulating hormone in experimental heart transplantation.

Colombo G, Gatti S, Turcatti F, Sordi A, Fassati LR, Bonino F, Lipton JM, Catania A

Journal of immunology (Baltimore, Md. : 1950)1 Sept 2005Cited by 18 (Europe PMC)

PMID16116233DOI10.4049/jimmunol.175.5.3391PepBankPUB-16116233

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rat heart grafts on postoperative day 1, NDP-alpha-MSH induced expression of cytoskeleton proteins.
In plain wordsIn rats with heart grafts, NDP-alpha-MSH raised the activity of genes for cell structure proteins.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseCytoskeleton protein expression, day 1
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
On postoperative day 1, the peptide induced expression of cytoskeleton proteins, intracellular kinases, transcription regulators, metallopeptidases, and protease inhibitors.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623301
02AnimalAnimal study (in vivo)Mechanism
In rat heart grafts on postoperative day 1, NDP-alpha-MSH induced expression of intracellular kinases.
In plain wordsIn rats with heart grafts, NDP-alpha-MSH raised the activity of genes for signaling enzymes.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseIntracellular kinase expression, day 1
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
On postoperative day 1, the peptide induced expression of cytoskeleton proteins, intracellular kinases, transcription regulators, metallopeptidases, and protease inhibitors.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623302
03AnimalAnimal study (in vivo)Mechanism
In rat heart grafts on postoperative day 1, NDP-alpha-MSH induced expression of transcription regulators.
In plain wordsIn rats with heart grafts, NDP-alpha-MSH raised the activity of genes that control other genes.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseTranscription regulator expression, day 1
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
On postoperative day 1, the peptide induced expression of cytoskeleton proteins, intracellular kinases, transcription regulators, metallopeptidases, and protease inhibitors.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623303
04AnimalAnimal study (in vivo)Mechanism
In rat heart grafts on postoperative day 1, NDP-alpha-MSH induced expression of metallopeptidases.
In plain wordsIn rats with heart grafts, NDP-alpha-MSH raised the activity of genes for protein-cutting enzymes.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseMetallopeptidase expression, day 1
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
On postoperative day 1, the peptide induced expression of cytoskeleton proteins, intracellular kinases, transcription regulators, metallopeptidases, and protease inhibitors.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623304
05AnimalAnimal study (in vivo)Mechanism
In rat heart grafts on postoperative day 1, NDP-alpha-MSH induced expression of protease inhibitors.
In plain wordsIn rats with heart grafts, NDP-alpha-MSH raised the activity of genes for protease inhibitors.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseProtease inhibitor expression, day 1
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
On postoperative day 1, the peptide induced expression of cytoskeleton proteins, intracellular kinases, transcription regulators, metallopeptidases, and protease inhibitors.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623305
06AnimalAnimal study (in vivo)Mechanism
In rat heart grafts, NDP-alpha-MSH repressed expression of immune mediators.
In plain wordsIn rats with heart grafts, NDP-alpha-MSH lowered the activity of immune genes.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseImmune mediator expression, day 1
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Conversely, NDP-alpha-MSH repressed immune, inflammatory, cell cycle, and protein turnover mediators.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623306
07AnimalAnimal study (in vivo)Mechanism
In rat heart grafts, NDP-alpha-MSH repressed expression of inflammatory mediators.
In plain wordsIn rats with heart grafts, NDP-alpha-MSH lowered the activity of inflammation genes.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseInflammatory mediator expression
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Conversely, NDP-alpha-MSH repressed immune, inflammatory, cell cycle, and protein turnover mediators.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623307
08AnimalAnimal study (in vivo)Mechanism
In rat heart grafts, NDP-alpha-MSH repressed expression of cell cycle mediators.
In plain wordsIn rats with heart grafts, NDP-alpha-MSH lowered the activity of cell cycle genes.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseCell cycle mediator expression
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Conversely, NDP-alpha-MSH repressed immune, inflammatory, cell cycle, and protein turnover mediators.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623308
09AnimalAnimal study (in vivo)Mechanism
In rat heart grafts, NDP-alpha-MSH repressed expression of protein turnover mediators.
In plain wordsIn rats with heart grafts, NDP-alpha-MSH lowered the activity of protein turnover genes.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseProtein turnover mediator expression
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Conversely, NDP-alpha-MSH repressed immune, inflammatory, cell cycle, and protein turnover mediators.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623309
10AnimalAnimal study (in vivo)Mechanism
In rat heart grafts, later effects of alpha-MSH treatment included down-regulation of the oxidative stress response.
In plain wordsIn rats with heart grafts, later treatment lowered the activity of oxidative stress response genes.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseOxidative stress response, later time point
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Later effects of alpha-MSH treatment included down-regulation of oxidative stress response and up-regulation of ion channels, calcium regulation proteins, phosphatidylinositol signaling system, and glycolipidic metabolism.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623310
11AnimalAnimal study (in vivo)Mechanism
In rat heart grafts, later effects of alpha-MSH treatment included up-regulation of ion channels.
In plain wordsIn rats with heart grafts, later treatment raised the activity of ion channel genes.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseIon channel expression, later time point
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Later effects of alpha-MSH treatment included down-regulation of oxidative stress response and up-regulation of ion channels, calcium regulation proteins, phosphatidylinositol signaling system, and glycolipidic metabolism.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623311
12AnimalAnimal study (in vivo)Mechanism
In rat heart grafts, later effects of alpha-MSH treatment included up-regulation of calcium regulation proteins.
In plain wordsIn rats with heart grafts, later treatment raised the activity of calcium control genes.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseCalcium regulation protein expression, later time point
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Later effects of alpha-MSH treatment included down-regulation of oxidative stress response and up-regulation of ion channels, calcium regulation proteins, phosphatidylinositol signaling system, and glycolipidic metabolism.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623312
13AnimalAnimal study (in vivo)Mechanism
In rat heart grafts, later effects of alpha-MSH treatment included up-regulation of the phosphatidylinositol signaling system.
In plain wordsIn rats with heart grafts, later treatment raised the activity of genes in a cell signaling system.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreasePhosphatidylinositol signaling system, later time point
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Later effects of alpha-MSH treatment included down-regulation of oxidative stress response and up-regulation of ion channels, calcium regulation proteins, phosphatidylinositol signaling system, and glycolipidic metabolism.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623313
14AnimalAnimal study (in vivo)Mechanism
In rat heart grafts, later effects of alpha-MSH treatment included up-regulation of glycolipidic metabolism.
In plain wordsIn rats with heart grafts, later treatment raised the activity of genes for sugar-fat metabolism.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseGlycolipidic metabolism, later time point
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Later effects of alpha-MSH treatment included down-regulation of oxidative stress response and up-regulation of ion channels, calcium regulation proteins, phosphatidylinositol signaling system, and glycolipidic metabolism.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623314
15AnimalAnimal study (in vivo)Mechanism
In rat heart grafts, NDP-alpha-MSH exerted its effects on both antigen-dependent and antigen-independent injury.
In plain wordsIn rats with heart grafts, NDP-alpha-MSH acted on both immune-driven and non-immune injury.
Peptide
Melanotan I (afamelanotide)
Outcome
Not applicableEffect on antigen-dependent and independent injury
Study
ratn: not reported in source
heart transplantation
Comparator
Saline
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
NDP-alpha-MSH exerted its effects on both Ag-dependent and -independent injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Gene expression profile was examined in heart grafts removed on postoperative days 1 and 4 from rats treated with saline or the synthetic alpha-MSH analog Nle4DPhe7 (NDP)-alpha-MSH.
Report a problemFND-1611623315

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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