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Study · Animal study (in vivo) · rat · 2010

8 results

Pancreatic neuronal melanocortin-4 receptor modulates serum insulin levels independent of leptin receptor.

Mansour M, White D, Wernette C, Dennis J, Tao YX, Collins R, Parker L, Morrison E

Endocrine7 Jan 2010Cited by 23 (Europe PMC)

PMID20963574 (opens in a new tab)DOI10.1007/s12020-009-9289-5 (opens in a new tab)PepBankPUB-20963574
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, third-ventricle infusion of NDP-MSH increased hypothalamic c-Fos mRNA.

    In plain wordsIn rats, NDP-MSH infused into the brain raised c-Fos messenger RNA in the hypothalamus.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseHypothalamic c-Fos mRNA
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · infusion via the third ventricleAs given in this study (rat).

    Source sentences

    Summary
    Subsequently, both hypothalamic and pancreatic c-Fos and Mc4r mRNAs were upregulated.
    2 context sentences
    Summary · context
    In order to determine the veracity of the hypothesis, we examined c-Fos, melanocortin-4 receptor (Mc4r), and alpha-melanocyte-stimulating hormone (α-MSH) expression levels in nondiabetic (intact leptin receptor signaling) and Zucker diabetic fatty (ZDF; leptin receptor deficiency) rats.
    Summary · context
    We infused rats via the third ventricle with the α-MSH analog Nle4, D-Phe7-α-MSH (NDP-MSH), a Mc4r agonist.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, third-ventricle infusion of NDP-MSH increased pancreatic c-Fos mRNA.

    In plain wordsIn rats, NDP-MSH infused into the brain raised c-Fos messenger RNA in the pancreas.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreasePancreatic c-Fos mRNA
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · infusion via the third ventricleAs given in this study (rat).

    Source sentences

    Summary
    Subsequently, both hypothalamic and pancreatic c-Fos and Mc4r mRNAs were upregulated.
    2 context sentences
    Summary · context
    In order to determine the veracity of the hypothesis, we examined c-Fos, melanocortin-4 receptor (Mc4r), and alpha-melanocyte-stimulating hormone (α-MSH) expression levels in nondiabetic (intact leptin receptor signaling) and Zucker diabetic fatty (ZDF; leptin receptor deficiency) rats.
    Summary · context
    We infused rats via the third ventricle with the α-MSH analog Nle4, D-Phe7-α-MSH (NDP-MSH), a Mc4r agonist.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, third-ventricle infusion of NDP-MSH increased hypothalamic Mc4r mRNA.

    In plain wordsIn rats, NDP-MSH infused into the brain raised Mc4r messenger RNA in the hypothalamus.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseHypothalamic Mc4r mRNA
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · infusion via the third ventricleAs given in this study (rat).

    Source sentences

    Summary
    Subsequently, both hypothalamic and pancreatic c-Fos and Mc4r mRNAs were upregulated.
    2 context sentences
    Summary · context
    In order to determine the veracity of the hypothesis, we examined c-Fos, melanocortin-4 receptor (Mc4r), and alpha-melanocyte-stimulating hormone (α-MSH) expression levels in nondiabetic (intact leptin receptor signaling) and Zucker diabetic fatty (ZDF; leptin receptor deficiency) rats.
    Summary · context
    We infused rats via the third ventricle with the α-MSH analog Nle4, D-Phe7-α-MSH (NDP-MSH), a Mc4r agonist.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, third-ventricle infusion of NDP-MSH increased pancreatic Mc4r mRNA.

    In plain wordsIn rats, NDP-MSH infused into the brain raised Mc4r messenger RNA in the pancreas.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreasePancreatic Mc4r mRNA
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · infusion via the third ventricleAs given in this study (rat).

    Source sentences

    Summary
    Subsequently, both hypothalamic and pancreatic c-Fos and Mc4r mRNAs were upregulated.
    2 context sentences
    Summary · context
    In order to determine the veracity of the hypothesis, we examined c-Fos, melanocortin-4 receptor (Mc4r), and alpha-melanocyte-stimulating hormone (α-MSH) expression levels in nondiabetic (intact leptin receptor signaling) and Zucker diabetic fatty (ZDF; leptin receptor deficiency) rats.
    Summary · context
    We infused rats via the third ventricle with the α-MSH analog Nle4, D-Phe7-α-MSH (NDP-MSH), a Mc4r agonist.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, immunohistochemistry showed increased Mc4r expression in nerves around pancreatic vessels and islets.

    In plain wordsIn rats, Mc4r protein was higher in nerves around pancreatic blood vessels and islets after NDP-MSH.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMc4r protein expression in pancreatic nerves
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · infusion via the third ventricleAs given in this study (rat).

    Source sentences

    Summary
    Likewise, immunohistochemical analysis showed that an increased Mc4r and α-MSH expression in nerves surrounding the pancreatic vasculature and islets.
    2 context sentences
    Summary · context
    In order to determine the veracity of the hypothesis, we examined c-Fos, melanocortin-4 receptor (Mc4r), and alpha-melanocyte-stimulating hormone (α-MSH) expression levels in nondiabetic (intact leptin receptor signaling) and Zucker diabetic fatty (ZDF; leptin receptor deficiency) rats.
    Summary · context
    We infused rats via the third ventricle with the α-MSH analog Nle4, D-Phe7-α-MSH (NDP-MSH), a Mc4r agonist.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, immunohistochemistry showed increased alpha-MSH expression in nerves around pancreatic vessels and islets.

    In plain wordsIn rats, alpha-MSH protein was higher in nerves around pancreatic blood vessels and islets after NDP-MSH.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Increasealpha-MSH expression in pancreatic nerves
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · infusion via the third ventricleAs given in this study (rat).

    Source sentences

    Summary
    Likewise, immunohistochemical analysis showed that an increased Mc4r and α-MSH expression in nerves surrounding the pancreatic vasculature and islets.
    2 context sentences
    Summary · context
    In order to determine the veracity of the hypothesis, we examined c-Fos, melanocortin-4 receptor (Mc4r), and alpha-melanocyte-stimulating hormone (α-MSH) expression levels in nondiabetic (intact leptin receptor signaling) and Zucker diabetic fatty (ZDF; leptin receptor deficiency) rats.
    Summary · context
    We infused rats via the third ventricle with the α-MSH analog Nle4, D-Phe7-α-MSH (NDP-MSH), a Mc4r agonist.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In nondiabetic and ZDF rats, the increases in c-Fos, alpha-MSH and Mc4r expression did not depend on leptin receptor function.

    In plain wordsIn rats, the rises in c-Fos, alpha-MSH and Mc4r did not depend on leptin receptor function.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeLeptin receptor dependence of c-Fos, alpha-MSH and Mc4r increases
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · infusion via the third ventricleAs given in this study (rat).

    Source sentences

    Summary
    Increases in c-Fos, α-MSH, and Mc4r expression were independent of leptin receptor function.
    2 context sentences
    Summary · context
    In order to determine the veracity of the hypothesis, we examined c-Fos, melanocortin-4 receptor (Mc4r), and alpha-melanocyte-stimulating hormone (α-MSH) expression levels in nondiabetic (intact leptin receptor signaling) and Zucker diabetic fatty (ZDF; leptin receptor deficiency) rats.
    Summary · context
    We infused rats via the third ventricle with the α-MSH analog Nle4, D-Phe7-α-MSH (NDP-MSH), a Mc4r agonist.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, NDP-MSH significantly reduced serum insulin, and the Mc4r blocker HS014 reversed this effect.

    In plain wordsIn rats, NDP-MSH lowered blood insulin, and a blocker of the Mc4r receptor reversed this.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseSerum insulin level
    Study

    ratn: not reported in source

    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · infusion via the third ventricleAs given in this study (rat).

    Source sentences

    Summary
    Conversely, serum insulin was significantly reduced by NDP-MSH treatment, an effect which was reversed by the Mc4r specific blocker HS014.
    2 context sentences
    Summary · context
    In order to determine the veracity of the hypothesis, we examined c-Fos, melanocortin-4 receptor (Mc4r), and alpha-melanocyte-stimulating hormone (α-MSH) expression levels in nondiabetic (intact leptin receptor signaling) and Zucker diabetic fatty (ZDF; leptin receptor deficiency) rats.
    Summary · context
    We infused rats via the third ventricle with the α-MSH analog Nle4, D-Phe7-α-MSH (NDP-MSH), a Mc4r agonist.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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