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Study · Animal study (in vivo) · rat · 2012

5 results

Protective action of NDP-MSH in experimental subarachnoid hemorrhage.

Gatti S, Lonati C, Acerbi F, Sordi A, Leonardi P, Carlin A, Gaini SM, Catania A

Experimental neurology2 Jan 2012Cited by 28 (Europe PMC)

PMID22230666 (opens in a new tab)DOI10.1016/j.expneurol.2011.12.039 (opens in a new tab)PepBankPUB-22230666
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats without injury, intrathecal NDP-MSH at a small concentration induced a tolerant basilar artery phenotype similar to that after ischemic preconditioning.

    In plain wordsIn rats without injury, a small amount of NDP-MSH given into the spinal fluid made the brain artery tolerant, as after preconditioning.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableBasilar artery phenotype without injury
    Study

    ratn: not reported in source

    Basilar artery in the absence of injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 ng · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Initial experiments examined effects of NDP-MSH on the basilar artery phenotype in the absence of injury. In these tests intrathecal injection of small concentrations (10ng) of the peptide induced a tolerant phenotype similar to that observed after ischemic preconditioning.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, NDP-MSH prevented most of the transcription changes in the basilar artery.

    In plain wordsIn rats with bleeding around the brain, NDP-MSH prevented most gene activity changes in a brain artery.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseBasilar artery transcriptional changes 4 hours after SAH
    Study

    ratn: not reported in source

    Experimental subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 μg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Treatment with NDP-MSH prevented most of these transcription changes
    2 context sentences
    Summary · context
    Then the effect of systemic treatment with NDP-MSH (100μg i.v.) on experimental SAH was evaluated.
    Summary · context
    SAH was induced by a single-blood injection into the cisterna magna.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, NDP-MSH decreased phosphorylation of ERK1/2.

    In plain wordsIn rats with bleeding around the brain, NDP-MSH lowered ERK1/2 activation in a brain artery.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseERK1/2 phosphorylation
    Study

    ratn: not reported in source

    Experimental subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 μg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Treatment with NDP-MSH prevented most of these transcription changes and decreased phosphorylation of extracellular-signal-regulated kinases (ERK1/2) and inhibitor protein IκBα.
    2 context sentences
    Summary · context
    Then the effect of systemic treatment with NDP-MSH (100μg i.v.) on experimental SAH was evaluated.
    Summary · context
    SAH was induced by a single-blood injection into the cisterna magna.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, NDP-MSH decreased phosphorylation of inhibitor protein IκBα.

    In plain wordsIn rats with bleeding around the brain, NDP-MSH lowered IκBα activation in a brain artery.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseIκBα phosphorylation
    Study

    ratn: not reported in source

    Experimental subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 μg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Treatment with NDP-MSH prevented most of these transcription changes and decreased phosphorylation of extracellular-signal-regulated kinases (ERK1/2) and inhibitor protein IκBα.
    2 context sentences
    Summary · context
    Then the effect of systemic treatment with NDP-MSH (100μg i.v.) on experimental SAH was evaluated.
    Summary · context
    SAH was induced by a single-blood injection into the cisterna magna.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, NDP-MSH significantly reduced vasospasm on day 5.

    In plain wordsIn rats with bleeding around the brain, NDP-MSH significantly reduced artery narrowing five days later.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseVasospasm at day 5
    Study

    ratn: not reported in source

    Experimental subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 μg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Vasospasm on day 5 was significantly reduced by NDP-MSH administration.
    2 context sentences
    Summary · context
    Then the effect of systemic treatment with NDP-MSH (100μg i.v.) on experimental SAH was evaluated.
    Summary · context
    SAH was induced by a single-blood injection into the cisterna magna.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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