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Study · Animal study (in vivo) · mouse · 2023

2 results

Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy.

Guan X, Chen B, Malhotra DK, Gohara AF, Dworkin LD, Gong R

Kidney international28 Oct 2022Cited by 11 (Europe PMC)

PMID36374665 (opens in a new tab)PMCIDPMC10431720 (opens in a new tab)DOI10.1016/j.kint.2022.09.025 (opens in a new tab)PepBankPUB-36374665
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice with nephrotoxic serum nephritis, NDP-MSH ameliorated experimental nephritis.

    In plain wordsIn mice with induced kidney inflammation, NDP-MSH reduced the kidney damage.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseExperimental nephritis severity in wild-type mice
    Study

    mousen: not reported in source

    Nephrotoxic serum nephritis in wild-type and MC1R null-mutant mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Melanocortin therapy, using Repository Corticotropin Injection (Acthar Gel), the pan-melanocortin receptor agonist NDP-MSH, or the MC1R agonist MS05, ameliorated experimental nephritis in wild-type mice but this effect was blunted in null mice.
    1 context sentence
    Summary · context
    Upon insult by rabbit nephrotoxic serum, MC1R null-mutant mice developed more severe crescentic glomerulonephritis than wild-type mice, marked by aggravated proteinuria, kidney dysfunction and histologic lesions.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In MC1R null-mutant mice with nephrotoxic serum nephritis, the beneficial effect of NDP-MSH was blunted compared with wild-type mice.

    In plain wordsIn mice lacking the MC1R receptor, NDP-MSH helped the damaged kidney less than in normal mice.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    MixedExperimental nephritis amelioration in MC1R null mice
    Study

    mousen: not reported in source

    Nephrotoxic serum nephritis in wild-type and MC1R null-mutant mice
    Comparator
    Wild-type mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Melanocortin therapy, using Repository Corticotropin Injection (Acthar Gel), the pan-melanocortin receptor agonist NDP-MSH, or the MC1R agonist MS05, ameliorated experimental nephritis in wild-type mice but this effect was blunted in null mice.
    1 context sentence
    Summary · context
    Upon insult by rabbit nephrotoxic serum, MC1R null-mutant mice developed more severe crescentic glomerulonephritis than wild-type mice, marked by aggravated proteinuria, kidney dysfunction and histologic lesions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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