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Study · Animal study (in vivo) · rat · 2002

5 results

alpha-Melanocyte-stimulating hormone protects the allograft in experimental heart transplantation.

Gatti S, Colombo G, Buffa R, Turcatti F, Garofalo L, Carboni N, Ferla L, Fassati LR, Lipton JM, Catania A

Transplantation1 Dec 2002Cited by 31 (Europe PMC)

PMID12499879 (opens in a new tab)DOI10.1097/00007890-200212270-00005 (opens in a new tab)PepBankPUB-12499879
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with heterotopic heart transplants, NDP-alpha-MSH significantly increased allograft survival versus saline.

    In plain wordsIn rats with transplanted hearts, NDP-alpha-MSH made the grafts survive longer than saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseAllograft survival
    Study

    ratn: not reported in source

    heterotopic cardiac allograft (Brown Norway to Lewis)
    Comparator
    Saline
    Outcome group
    Immune response · Cardiovascular
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    NDP-alpha-MSH treatment caused a significant increase in allograft survival
    2 context sentences
    Summary · context
    Donor cardiac grafts (Brown Norway) were transplanted heterotopically into the abdomen of recipient (Lewis) rats.
    Summary · context
    Treatments consisted of intraperitoneal injections of Nle DPhe -alpha-MSH (NDP-alpha-MSH) or saline from the time of transplantation until sacrifice or spontaneous rejection.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with heterotopic heart transplants, NDP-alpha-MSH markedly decreased leukocyte infiltration of the allograft versus saline.

    In plain wordsIn rats with transplanted hearts, NDP-alpha-MSH reduced immune cell entry into the graft compared with saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseLeukocyte infiltration of the allograft
    Study

    ratn: not reported in source

    heterotopic cardiac allograft (Brown Norway to Lewis)
    Comparator
    Saline
    Outcome group
    Immune response · Cardiovascular
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    NDP-alpha-MSH treatment caused a significant increase in allograft survival and a marked decrease in leukocyte infiltration.
    2 context sentences
    Summary · context
    Donor cardiac grafts (Brown Norway) were transplanted heterotopically into the abdomen of recipient (Lewis) rats.
    Summary · context
    Treatments consisted of intraperitoneal injections of Nle DPhe -alpha-MSH (NDP-alpha-MSH) or saline from the time of transplantation until sacrifice or spontaneous rejection.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with heterotopic heart transplants, NDP-alpha-MSH significantly inhibited the expression of endothelin 1 in the allograft versus saline.

    In plain wordsIn rats with transplanted hearts, NDP-alpha-MSH lowered endothelin 1 in the graft compared with saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseEndothelin 1 expression in the allograft
    Study

    ratn: not reported in source

    heterotopic cardiac allograft (Brown Norway to Lewis)
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Expression of molecules such as endothelin 1, chemokines, and adhesion molecules, which are involved in allograft rejection, was significantly inhibited in NDP-alpha-MSH-treated rats.
    2 context sentences
    Summary · context
    Donor cardiac grafts (Brown Norway) were transplanted heterotopically into the abdomen of recipient (Lewis) rats.
    Summary · context
    Treatments consisted of intraperitoneal injections of Nle DPhe -alpha-MSH (NDP-alpha-MSH) or saline from the time of transplantation until sacrifice or spontaneous rejection.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with heterotopic heart transplants, NDP-alpha-MSH significantly inhibited the expression of chemokines in the allograft versus saline.

    In plain wordsIn rats with transplanted hearts, NDP-alpha-MSH lowered chemokines in the graft compared with saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseChemokine expression in the allograft
    Study

    ratn: not reported in source

    heterotopic cardiac allograft (Brown Norway to Lewis)
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Expression of molecules such as endothelin 1, chemokines, and adhesion molecules, which are involved in allograft rejection, was significantly inhibited in NDP-alpha-MSH-treated rats.
    2 context sentences
    Summary · context
    Donor cardiac grafts (Brown Norway) were transplanted heterotopically into the abdomen of recipient (Lewis) rats.
    Summary · context
    Treatments consisted of intraperitoneal injections of Nle DPhe -alpha-MSH (NDP-alpha-MSH) or saline from the time of transplantation until sacrifice or spontaneous rejection.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with heterotopic heart transplants, NDP-alpha-MSH significantly inhibited the expression of adhesion molecules in the allograft versus saline.

    In plain wordsIn rats with transplanted hearts, NDP-alpha-MSH lowered adhesion molecules in the graft compared with saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseAdhesion molecule expression in the allograft
    Study

    ratn: not reported in source

    heterotopic cardiac allograft (Brown Norway to Lewis)
    Comparator
    Saline
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Expression of molecules such as endothelin 1, chemokines, and adhesion molecules, which are involved in allograft rejection, was significantly inhibited in NDP-alpha-MSH-treated rats.
    2 context sentences
    Summary · context
    Donor cardiac grafts (Brown Norway) were transplanted heterotopically into the abdomen of recipient (Lewis) rats.
    Summary · context
    Treatments consisted of intraperitoneal injections of Nle DPhe -alpha-MSH (NDP-alpha-MSH) or saline from the time of transplantation until sacrifice or spontaneous rejection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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