Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268.

Giuliani D, Ottani A, Minutoli L, Stefano VD, Galantucci M, Bitto A, Zaffe D, Altavilla D, Botticelli AR, Squadrito F, Guarini S

Brain, behavior, and immunity5 Apr 2009Cited by 29 (Europe PMC)

PMID19345727DOI10.1016/j.bbi.2009.03.009PepBankPUB-19345727

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In gerbils with global cerebral ischemia, delayed NDP-alpha-MSH treatment significantly reduced hippocampal damage.
In plain wordsIn gerbils after a stroke, NDP-alpha-MSH given later reduced damage in the hippocampus.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseHippocampal damage
Study
gerbiln: not reported in source
Global cerebral ischemia by occlusion of both carotid arteries
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
nanomolar dose · every 12 h for 11 daysAs given in this study (gerbil).
Source sentences
Summary
Treatment with NDP-alpha-MSH significantly reduced hippocampal damage, including neuronal death
2 context sentences(design, population, supporting numbers)
Summary · context
A 10-min period of global cerebral ischemia was induced by occluding both common carotid arteries in gerbils.
Summary · context
Treatment with a nanomolar dose of NDP-alpha-MSH (every 12h for 11 days) was performed starting 3h or 9h after stroke induction; where indicated, gerbils were pretreated with the melanocortin MC(4) receptor antagonist HS024.
Report a problemFND-1934572701
02AnimalAnimal study (in vivo)Efficacy outcome
In gerbils with global cerebral ischemia, delayed NDP-alpha-MSH treatment significantly reduced neuronal death in the hippocampus.
In plain wordsIn gerbils after a stroke, NDP-alpha-MSH given later reduced the death of nerve cells in the hippocampus.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseHippocampal neuronal death
Study
gerbiln: not reported in source
Global cerebral ischemia by occlusion of both carotid arteries
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
nanomolar dose · every 12 h for 11 daysAs given in this study (gerbil).
Source sentences
Summary
Treatment with NDP-alpha-MSH significantly reduced hippocampal damage, including neuronal death
2 context sentences(design, population, supporting numbers)
Summary · context
A 10-min period of global cerebral ischemia was induced by occluding both common carotid arteries in gerbils.
Summary · context
Treatment with a nanomolar dose of NDP-alpha-MSH (every 12h for 11 days) was performed starting 3h or 9h after stroke induction; where indicated, gerbils were pretreated with the melanocortin MC(4) receptor antagonist HS024.
Report a problemFND-1934572702
03AnimalAnimal study (in vivo)Efficacy outcome
In gerbils with global cerebral ischemia, delayed NDP-alpha-MSH treatment improved learning and memory recovery.
In plain wordsIn gerbils after a stroke, NDP-alpha-MSH given later improved recovery of learning and memory.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseLearning and memory recovery (Morris water maze)
Study
gerbiln: not reported in source
Global cerebral ischemia by occlusion of both carotid arteries
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
nanomolar dose · every 12 h for 11 daysAs given in this study (gerbil).
Source sentences
Summary
Treatment with NDP-alpha-MSH significantly reduced hippocampal damage, including neuronal death, and improved learning and memory recovery.
3 context sentences(design, population, supporting numbers)
Summary · context
Animals were subjected to the Morris water-maze test (four sessions from 4 to 50 days after the ischemic episode).
Summary · context
A 10-min period of global cerebral ischemia was induced by occluding both common carotid arteries in gerbils.
Summary · context
Treatment with a nanomolar dose of NDP-alpha-MSH (every 12h for 11 days) was performed starting 3h or 9h after stroke induction; where indicated, gerbils were pretreated with the melanocortin MC(4) receptor antagonist HS024.
Report a problemFND-1934572703
04AnimalAnimal study (in vivo)Mechanism
In gerbils with global cerebral ischemia, the protective effect of NDP-alpha-MSH was associated with Zif268 overexpression with both treatment schedules.
In plain wordsIn gerbils after a stroke, the protective effect of NDP-alpha-MSH went with higher Zif268 gene activity.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseHippocampal Zif268 expression
Study
gerbiln: not reported in source
Global cerebral ischemia by occlusion of both carotid arteries
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
nanomolar dose · every 12 h for 11 daysAs given in this study (gerbil).
Source sentences
Summary
associated with Zif268 overexpression, with both schedules of NDP-alpha-MSH treatment.
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty days after stroke, histological damage and Zif268 expression were investigated in the hippocampus.
Summary · context
A 10-min period of global cerebral ischemia was induced by occluding both common carotid arteries in gerbils.
Summary · context
Treatment with a nanomolar dose of NDP-alpha-MSH (every 12h for 11 days) was performed starting 3h or 9h after stroke induction; where indicated, gerbils were pretreated with the melanocortin MC(4) receptor antagonist HS024.
Report a problemFND-1934572704
05AnimalAnimal study (in vivo)Efficacy outcome
In gerbils with global cerebral ischemia, the protective effect of NDP-alpha-MSH lasted at least 50 days.
In plain wordsIn gerbils after a stroke, the protective effect of NDP-alpha-MSH lasted at least 50 days.
Peptide
Melanotan I (afamelanotide)
Outcome
Not applicableDuration of protective effect
Study
gerbiln: not reported in source
Global cerebral ischemia by occlusion of both carotid arteries
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
nanomolar dose · every 12 h for 11 daysAs given in this study (gerbil).
Measurements
duration of protective effect
≥ 50 days
gerbils
Source sentences
Summary
This protective effect was long-lasting (50 days, at least)
2 context sentences(design, population, supporting numbers)
Summary · context
A 10-min period of global cerebral ischemia was induced by occluding both common carotid arteries in gerbils.
Summary · context
Treatment with a nanomolar dose of NDP-alpha-MSH (every 12h for 11 days) was performed starting 3h or 9h after stroke induction; where indicated, gerbils were pretreated with the melanocortin MC(4) receptor antagonist HS024.
Report a problemFND-1934572705
06AnimalAnimal study (in vivo)Mechanism
In gerbils with global cerebral ischemia, blockade of MC4 receptors prevented the effects of NDP-alpha-MSH treatment.
In plain wordsIn gerbils after a stroke, blocking MC4 receptors stopped the benefits of NDP-alpha-MSH.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseProtective effects after MC4 receptor blockade
Study
gerbiln: not reported in source
Global cerebral ischemia by occlusion of both carotid arteries
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
nanomolar dose · every 12 h for 11 daysAs given in this study (gerbil).
Source sentences
Summary
Pharmacological blockade of MC(4) receptors prevented these effects.
2 context sentences(design, population, supporting numbers)
Summary · context
A 10-min period of global cerebral ischemia was induced by occluding both common carotid arteries in gerbils.
Summary · context
Treatment with a nanomolar dose of NDP-alpha-MSH (every 12h for 11 days) was performed starting 3h or 9h after stroke induction; where indicated, gerbils were pretreated with the melanocortin MC(4) receptor antagonist HS024.
Report a problemFND-1934572706

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Version history

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Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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