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Study · In vitro (cells) · mouse · 1996

2 results

Major pharmacological distinction of the ACTH receptor from other melanocortin receptors.

Schiöth HB, Chhajlani V, Muceniece R, Klusa V, Wikberg JE

Life sciences1 Jan 1996Cited by 119 (Europe PMC)

PMID8761313 (opens in a new tab)DOI10.1016/0024-3205(96)00370-0 (opens in a new tab)PepBankPUB-08761313
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In mouse Y1 cells, NDP-MSH could not compete with the binding of labelled ACTH(1-39) to the ACTH receptor.

    In plain wordsIn mouse cells in the lab, NDP-MSH did not displace ACTH from the ACTH receptor.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeCompetition with labelled ACTH(1-39) binding at the MC2R
    Study

    mousen: not reported in source

    Y1 adrenocortical cells expressing ACTH receptors (MC2R)
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, none of the melanocortin peptides NDP-MSH, alpha-MSH, beta-MSH or gamma 1-MSH could compete with the binding of the labelled ACTH(1-39).
    1 context sentence
    Summary · context
    The mouse adrenocortical cell line Y1, that expresses ACTH receptors (MC2R), was used to probe the binding of ACTH and MSH peptides by using radio-labelled ACTH (1-39).
  2. 02LabIn vitro (cells)Activity measurement

    In Y1 cells transfected with MC1, MC3 or MC4 receptor DNA, characteristic binding of [125I]NDP-MSH appeared for each receptor subtype.

    In plain wordsIn mouse cells in the lab, NDP-MSH bound the MC1, MC3 and MC4 receptors once those receptors were added.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicable[125I]NDP-MSH binding at MC1, MC3 and MC4 receptors
    Study

    mousen: not reported in source

    Y1 cells transfected with MC1, MC3 or MC4 receptor DNA
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When other MC receptor subtype DNAs (MC1, MC3 and MC4) were transfected into the Y1 cells, characteristic binding of the [125I]NDP-MSH appeared for each of the receptor subtype, but no specific binding was present in non-transfected cells.
    1 context sentence
    Summary · context
    The mouse adrenocortical cell line Y1, that expresses ACTH receptors (MC2R), was used to probe the binding of ACTH and MSH peptides by using radio-labelled ACTH (1-39).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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